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TdT chimera (Loop1 of pol mu) - apoenzyme

Analyse TdT chimera (Loop1 of pol mu) - apoenzyme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6GO3
Type
protein
Length
343 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
2.2
Source
Mus musculus
Molecule
DNA nucleotidylexotransferase,DNA-directed DNA/RNA polymerase mu,DNA…
EC
2.7.7.31, 2.7.7.7
UniProt
P09838, Q9JIW4
Pockets
1 · best druggability 0.60

Structure

x-ray diffraction · resolution 2.2 · 1 distinct chain · 51% helix, 15% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADNA nucleotidylexotransferase,DNA-directed DNA/RNA polymerase mu,DNA nucleotidylexotransferase (EC 2.7.7.31, 2.7.7.7)protein34351% helix, 15% strandP09838, Q9JIW4

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
15290.600.7461empty

Compared structures

  • 6GO3 · Tdt chimera (LOOP1 of pol mu) - apoenzyme · the same entry in another collection · chain A against A, TM-score 1.00
  • P09838 · AlphaFold monomer V2.0 prediction for DNA nucleotidylexotransferase (P09838) · a predicted model of the same protein · chain A against A, TM-score 1.00
  • Q9JIW4 · AlphaFold monomer V2.0 prediction for DNA-directed DNA/RNA polymerase mu (Q9JIW4) · a predicted model of the same protein · chain A against A, TM-score 0.94

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