Research workbench
Solution structure of the superactive monomeric des-[PHE(B25)] human insulin mutant. elucidation of the structural basis for the monomerization of the des-[PHE(B25)] insulin and the dimerization of native insulin
Analyse Solution structure of the superactive monomeric des-[PHE(B25)] human insulin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1MHJ
- Type
- protein
- Length
- 50 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- NOT
- Source
- Homo sapiens
- Molecule
- Insulin
- UniProt
- P01308
Structure
solution nmr · resolution NOT · 2 distinct chains · 54% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin | protein | 21 | 67% helix, 0% strand | P01308 |
| B | Insulin | protein | 29 | 45% helix, 0% strand | P01308 |
Interfaces
1 interface between chains.
- A–B · 731 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 1MHJ · Solution structure of the superactive monomeric des-[PHE(B25)] human insulin mutant.… · the same entry in another collection · chain A against A, TM-score 1.00
- P01308 · AlphaFold monomer V2.0 prediction for insulin (P01308) · a predicted model of the same protein · chain B against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 1MHJ · PDBe 1MHJ · UniProt P01308
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