Research workbench
Structure of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase Complexed with AMP
Analyse Structure of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase Complexed… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1MF1
- Type
- protein
- Length
- 430 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.7
- Source
- Mus musculus
- Molecule
- Adenylosuccinate Synthetase
- EC
- 6.3.4.4
- UniProt
- P28650
- Ligands
- AMP
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · resolution 2.7 · 1 distinct chain · 37% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylosuccinate Synthetase (EC 6.3.4.4) | protein | 430 | 37% helix, 21% strand | P28650 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 400 | 0.73 | 0.84 | 45 | AMP |
| 2 | 229 | 0.64 | 0.83 | 31 | ACT |
| 3 | 65 | 0.33 | 0.76 | 13 | empty |
Compared structures
- 1MF1 · Structure of the recombinant mouse-muscle adenylosuccinate synthetase complexed with AMP · the same entry in another collection · chain A against A, TM-score 1.00
- P28650 · AlphaFold monomer V2.0 prediction for adenylosuccinate synthetase isozyme 1 (P28650) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28650
- Elsewhere: RCSB PDB 1MF1 · PDBe 1MF1 · UniProt P28650
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