MolNFT v1 · #14617 · protein
Structure of the recombinant mouse-muscle adenylosuccinate synthetase complexed with AMP
1MF1: “Structure of the recombinant mouse-muscle adenylosuccinate synthetase complexed with AMP”. X-ray diffraction, 1 ligand (AMP), 3 pockets (best druggability 0.73). MolNFT v1 #14617 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1MF1
- Type
- protein
- Length
- 430 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylosuccinate synthetase
- EC
- 6.3.4.4
- UniProt
- P28650
- Ligands
- AMP
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylosuccinate synthetase (EC 6.3.4.4) | protein | 430 | 37% helix, 21% strand | P28650 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 400 | 0.73 | 0.84 | 45 | AMP |
| 2 | 229 | 0.64 | 0.83 | 31 | ACT |
| 3 | 65 | 0.33 | 0.76 | 13 | empty |
Compared structures
- 1MF1 · Structure of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase Complexed with AMP · the same entry in another collection · chain A against A, TM-score 1.00
- P28650 · AlphaFold monomer V2.0 prediction for adenylosuccinate synthetase isozyme 1 (P28650) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28650
- Elsewhere: RCSB PDB 1MF1 · PDBe 1MF1 · UniProt P28650
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