Research workbench

The crystal structure of 4-cyclohexylbenzoate-bound CYP199A4

Analyse The crystal structure of 4-cyclohexylbenzoate-bound CYP199A4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6C2D
Type: protein
Length: 393 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.79
Source: Rhodopseudomonas palustris HaA2
Molecule: Cytochrome P450
UniProt: Q2IU02
Ligands: HEM, EH1, CL
Pockets: 2 · best druggability 0.86

Structure

x-ray diffraction · resolution 1.79 · 1 distinct chain · 49% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome P450	protein	393	49% helix, 13% strand	Q2IU02

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
EH1 · 4-cyclohexylbenzoic acid · ligand · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	398	0.86	0.94	50	HEM, EH1
2	125	0.41	0.76	22	empty

Compared structures

6C2D · The crystal structure of 4-cyclohexylbenzoate-bound CYP199A4 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2IU02
Elsewhere: RCSB PDB 6C2D · PDBe 6C2D · UniProt Q2IU02

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.