Research workbench
Crystal structure of VACV D13 F486A mutant
Analyse Crystal structure of VACV D13 F486A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BEG
- Type
- protein
- Length
- 1,618 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.1
- Source
- Vaccinia virus WR
- Molecule
- Scaffold protein D13
- UniProt
- P68440
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · resolution 3.1 · 3 distinct chains · 15% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Scaffold protein D13 | protein | 542 | 16% helix, 40% strand | P68440 |
| B | Scaffold protein D13 | protein | 544 | 15% helix, 40% strand | P68440 |
| C | Scaffold protein D13 | protein | 532 | 14% helix, 41% strand | P68440 |
Ligands and binding sites
- FMT · Formic acid · additive · 7 copies · chains A, B, C
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1002 | 0.84 | 0.85 | 104 | empty |
| 2 | 1123 | 0.83 | 0.84 | 107 | FMT |
| 3 | 995 | 0.82 | 0.83 | 103 | FMT |
| 4 | 497 | 0.64 | 0.77 | 65 | empty |
| 5 | 99 | 0.49 | 0.81 | 24 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2987 Ų buried · 38 hydrogen bonds · protein-protein
- B–C · 2731 Ų buried · 31 hydrogen bonds · protein-protein
- A–C · 2532 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 6BEG · Crystal structure of vacv D13 F486A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68440
- Elsewhere: RCSB PDB 6BEG · PDBe 6BEG · UniProt P68440
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