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Solution structure for human HSP70 substrate binding domain

Analyse Solution structure for human HSP70 substrate binding domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5XI9
Type: protein
Length: 185 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: NOT
Source: Homo sapiens
Molecule: Heat shock 70 kDa protein 1A
UniProt: P0DMV8
Pockets: 2 · best druggability 0.71

Structure

solution nmr · resolution NOT · 1 distinct chain · 14% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock 70 kDa protein 1A	protein	185	14% helix, 32% strand	P0DMV8

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	157	0.71	0.89	26	empty
2	74	0.33	0.76	20	empty

Compared structures

5XI9 · Solution structure for human HSP70 substrate binding domain · the same entry in another collection · chain A against A, TM-score 1.00
P0DMV8 · AlphaFold monomer V2.0 prediction for heat shock 70 kda protein 1A (P0DMV8) · a predicted model of the same protein · chain A against A, TM-score 0.57

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DMV8
Elsewhere: RCSB PDB 5XI9 · PDBe 5XI9 · UniProt P0DMV8

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