Research workbench

Uracil-DNA glycosylase

Analyse Uracil-DNA glycosylase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1LAU
Type: protein + DNA
Length: 231 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.8
Source: Human herpesvirus 1; SYNTHETIC CONSTRUCT
Molecule: DNA (5'-D(*TP*TP*T)-3'); Protein (uracil-DNA glycosylase (E.C.3.2.2.-))
UniProt: P10186
Pockets: 1 · best druggability 0.41

Structure

x-ray diffraction · resolution 1.8 · 2 distinct chains · 43% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D	DNA (5'-D(TPTP*T)-3')	dna	3	—	—
E	Protein (uracil-DNA glycosylase (E.C.3.2.2.-))	protein	228	43% helix, 11% strand	P10186

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	122	0.41	0.76	22	empty

Interfaces

1 interface between chains.

D–E · 413 Å² buried · 8 hydrogen bonds · protein-nucleic

Compared structures

1LAU · Uracil-DNA glycosylase · the same entry in another collection · chain D against D, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10186
Elsewhere: RCSB PDB 1LAU · PDBe 1LAU · UniProt P10186

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.