Research workbench

Structure of apo P1 form of Candida albicans FKBP12

Analyse Structure of apo P1 form of Candida albicans FKBP12 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5HTG
Type: protein
Length: 244 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.4
Source: Candida albicans (strain SC5314 / ATCC MYA-2876)
Molecule: FK506-binding protein 1
EC: 5.2.1.8
UniProt: P28870
Pockets: 5 · best druggability 0.49

Structure

x-ray diffraction · resolution 2.4 · 1 distinct chain · 15% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	FK506-binding protein 1 (EC 5.2.1.8)	protein	122	15% helix, 36% strand	P28870

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	161	0.49	0.78	42	empty
2	61	0.36	0.79	15	empty
3	74	0.35	0.76	17	empty
4	57	0.33	0.76	14	empty
5	53	0.31	0.76	15	empty

Interfaces

1 interface between chains.

A–B · 688 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

5HTG · Structure of apo P1 form of candida albicans FKBP12 · the same entry in another collection · chain A against A, TM-score 1.00
P28870 · AlphaFold monomer V2.0 prediction for FK506-binding protein 1 (P28870) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28870
Elsewhere: RCSB PDB 5HTG · PDBe 5HTG · UniProt P28870

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.