Research workbench

RIP2 Kinase Catalytic Domain (1 - 310)

Analyse RIP2 Kinase Catalytic Domain (1 - 310) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5AR2
Type: protein
Length: 562 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.44
Source: HOMO SAPIENS
Molecule: Receptor-interacting SERINE/THREONINE-protein kinase 2
EC: 2.7.11.1
UniProt: O43353
Ligands: CA
Pockets: 7 · best druggability 0.83

Structure

x-ray diffraction · resolution 2.44 · 2 distinct chains · 38% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-interacting SERINE/THREONINE-protein kinase 2 (EC 2.7.11.1)	protein	277	39% helix, 16% strand	O43353
B	Receptor-interacting SERINE/THREONINE-protein kinase 2 (EC 2.7.11.1)	protein	285	38% helix, 17% strand	O43353

Ligands and binding sites

CA · Calcium ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1075	0.83	0.84	85	empty
2	398	0.64	0.78	44	empty
3	282	0.59	0.78	28	empty
4	134	0.48	0.78	26	empty
5	65	0.37	0.79	17	empty

Interfaces

1 interface between chains.

A–B · 1881 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

5AR2 · RIP2 kinase catalytic domain (1 - 310) · the same entry in another collection · chain A against A, TM-score 1.00
O43353 · AlphaFold monomer V2.0 prediction for receptor-interacting SERINE/THREONINE-protein… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43353
Elsewhere: RCSB PDB 5AR2 · PDBe 5AR2 · UniProt O43353

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