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Crystal Structure of the Bacteriophage T4 recombination mediator protein UvsY, Lattice Type II

Analyse Crystal Structure of the Bacteriophage T4 recombination mediator protein UvsY… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
4ZWR
Type
protein
Length
926 residues
Chains
7
Method
x-ray diffraction
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
3.3857
Source
Enterobacteria phage T4
Molecule
Recombination protein uvsY
UniProt
P04537
Pockets
13 · best druggability 0.61

Structure

x-ray diffraction · resolution 3.3857 · 4 distinct chains · 78% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, BRecombination protein uvsYprotein13677% helix, 0% strandP04537
C, E, FRecombination protein uvsYprotein13777% helix, 0% strandP04537
DRecombination protein uvsYprotein13576% helix, 0% strandP04537
GRecombination protein uvsYprotein10883% helix, 0% strandP04537

Pockets

13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1720.610.9016empty
2660.540.8718empty
3740.530.8518empty
4830.520.8420empty
5660.480.8417empty

Interfaces

7 interfaces between chains.

  • C–D · 1547 Ų buried · 14 hydrogen bonds · protein-protein
  • B–C · 1526 Ų buried · 14 hydrogen bonds · protein-protein
  • A–B · 1518 Ų buried · 16 hydrogen bonds · protein-protein
  • D–E · 1466 Ų buried · 11 hydrogen bonds · protein-protein
  • E–F · 1456 Ų buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 40 modified (engineered).

Compared structures

  • 4ZWR · Crystal structure of the bacteriophage T4 recombination mediator protein uvsy, lattice… · the same entry in another collection · chain A against A, TM-score 1.00

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