Research workbench
Structure of mouse importin a1 bound to Pom121NLS
Analyse Structure of mouse importin a1 bound to Pom121NLS in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4YI0
- Type
- protein
- Length
- 452 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.806
- Source
- Mus musculus; Rattus norvegicus
- Molecule
- Importin subunit alpha-1; Nuclear envelope pore membrane protein POM 121
- UniProt
- P52293, P52591
- Pockets
- 4 · best druggability 0.50
Structure
x-ray diffraction · resolution 1.806 · 2 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Importin subunit alpha-1 | protein | 425 | 74% helix, 0% strand | P52293 |
| A | Nuclear envelope pore membrane protein POM 121 | protein | 27 | 0% helix, 0% strand | P52591 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 181 | 0.50 | 0.77 | 22 | empty |
| 2 | 114 | 0.46 | 0.79 | 17 | empty |
| 3 | 74 | 0.45 | 0.81 | 12 | empty |
| 4 | 99 | 0.35 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- C–A · 1544 Ų buried · 51 hydrogen bonds · protein-protein
Compared structures
- 4YI0 · Structure of mouse importin A1 bound to POM121NLS · the same entry in another collection · chain A against A, TM-score 1.00
- P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain C against A, TM-score 0.99
- P52591 · AlphaFold monomer V2.0 prediction for nuclear envelope pore membrane protein pom 121… · a predicted model of the same protein · chain A against A, TM-score 0.20
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt P52591
- Elsewhere: RCSB PDB 4YI0 · PDBe 4YI0 · UniProt P52293 · UniProt P52591
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.