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Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding ProteinII in complex with Retinal after 24 h incubation and 1 hour UV irradiation at 1.92 angstrom - 1st cycle

Analyse Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4YBU
Type: protein
Length: 137 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.924
Source: Homo sapiens
Molecule: Cellular retinoic acid-binding protein 2
UniProt: P29373
Ligands: RET
Pockets: 1 · best druggability 0.69

Structure

x-ray diffraction · resolution 1.924 · 1 distinct chain · 13% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cellular retinoic acid-binding protein 2	protein	137	13% helix, 55% strand	P29373

Ligands and binding sites

RET · Retinal · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	370	0.69	0.81	34	RET

Modifications

Observed in the structure: 1 cofactor (retinal Schiff base).

Compared structures

4YBU · Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human cellular… · the same entry in another collection · chain A against A, TM-score 1.00
P29373 · AlphaFold monomer V2.0 prediction for cellular retinoic acid-binding protein 2 (P29373) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29373
Elsewhere: RCSB PDB 4YBU · PDBe 4YBU · UniProt P29373

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