Research workbench
Mechanistic insights into anchorage of the contractile ring from yeast to humans
Analyse Mechanistic insights into anchorage of the contractile ring from yeast to humans in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XOH
- Type
- protein
- Length
- 802 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.801
- Source
- Schizosaccharomyces pombe (strain 972 / ATCC 24843)
- Molecule
- Division mal foutue 1 protein
- UniProt
- P78953
- Pockets
- 9 · best druggability 0.82
Structure
x-ray diffraction · resolution 2.801 · 3 distinct chains · 13% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Division mal foutue 1 protein | protein | 268 | 16% helix, 49% strand | P78953 |
| A | Division mal foutue 1 protein | protein | 266 | 14% helix, 50% strand | P78953 |
| B | Division mal foutue 1 protein | protein | 268 | 10% helix, 47% strand | P78953 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1081 | 0.82 | 0.83 | 108 | empty |
| 2 | 174 | 0.54 | 0.80 | 31 | empty |
| 3 | 50 | 0.51 | 0.88 | 17 | empty |
| 4 | 62 | 0.45 | 0.83 | 18 | empty |
| 5 | 89 | 0.41 | 0.78 | 15 | empty |
Interfaces
3 interfaces between chains.
- C–A · 1082 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 1016 Ų buried · 23 hydrogen bonds · protein-protein
- C–B · 290 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 4XOH · Mechanistic insights into anchorage of the contractile ring from yeast to humans · the same entry in another collection · chain A against A, TM-score 1.00
- P78953 · AlphaFold monomer V2.0 prediction for division mal foutue 1 protein (P78953) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78953
- Elsewhere: RCSB PDB 4XOH · PDBe 4XOH · UniProt P78953
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