MolNFT v1 · #110168 · protein
Mechanistic insights into anchorage of the contractile ring from yeast to humans
4XOH · Division mal foutue 1 protein: “Mechanistic insights into anchorage of the contractile ring from yeast to humans”. X-ray diffraction, 9 pockets (best druggability 0.82). MolNFT v1 #110168 on GenesisL1: 3D structure, binding sites…
- PDB
- 4XOH
- Type
- protein
- Length
- 802 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Division mal foutue 1 protein
- UniProt
- P78953
- Pockets
- 9 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 13% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Division mal foutue 1 protein | protein | 268 | 16% helix, 49% strand | P78953 |
| A | Division mal foutue 1 protein | protein | 266 | 14% helix, 50% strand | P78953 |
| B | Division mal foutue 1 protein | protein | 268 | 10% helix, 47% strand | P78953 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1081 | 0.82 | 0.83 | 108 | empty |
| 2 | 174 | 0.54 | 0.80 | 31 | empty |
| 3 | 50 | 0.51 | 0.88 | 17 | empty |
| 4 | 62 | 0.45 | 0.83 | 18 | empty |
| 5 | 89 | 0.41 | 0.78 | 15 | empty |
Interfaces
3 interfaces between chains.
- C–A · 1082 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 1016 Ų buried · 23 hydrogen bonds · protein-protein
- C–B · 290 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 4XOH · Mechanistic insights into anchorage of the contractile ring from yeast to humans · the same entry in another collection · chain C against C, TM-score 1.00
- P78953 · AlphaFold monomer V2.0 prediction for division mal foutue 1 protein (P78953) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78953
- Elsewhere: RCSB PDB 4XOH · PDBe 4XOH · UniProt P78953
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.