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Crystal Structure of Drosophila AnCE

Analyse Crystal Structure of Drosophila AnCE in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1J38
Type: protein
Length: 1,196 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.6
Source: Drosophila melanogaster
Molecule: angiotensin converting enzyme
EC: 3.4.15.1
UniProt: Q10714
Ligands: ZN
Pockets: 8 · best druggability 0.87

Structure

x-ray diffraction · resolution 2.6 · 1 distinct chain · 59% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	angiotensin converting enzyme (EC 3.4.15.1)	protein	598	59% helix, 4% strand	Q10714

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1162	0.87	0.88	124	empty
2	551	0.85	0.91	72	empty
3	531	0.65	0.76	50	empty
4	74	0.56	0.87	10	empty
5	72	0.47	0.83	13	empty

Interfaces

1 interface between chains.

A–B · 525 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

1J38 · Crystal structure of drosophila ance · the same entry in another collection · chain A against A, TM-score 1.00
Q10714 · AlphaFold monomer V2.0 prediction for angiotensin-converting enzyme (Q10714) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q10714
Elsewhere: RCSB PDB 1J38 · PDBe 1J38 · UniProt Q10714

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