Research workbench
Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab.
Analyse Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1IQD
- Type
- protein
- Length
- 564 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2
- Source
- Homo sapiens
- Molecule
- Human monoclonal BO2C11 Fab light chain; Human monoclonal BO2C11 Fab heavy chain; Human…
- UniProt
- P00451
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · resolution 2 · 3 distinct chains · 6% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Human monoclonal BO2C11 Fab light chain | protein | 208 | 7% helix, 54% strand | — |
| B | Human monoclonal BO2C11 Fab heavy chain | protein | 200 | 8% helix, 53% strand | — |
| C | Human factor VIII | protein | 156 | 4% helix, 52% strand | P00451 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 413 | 0.57 | 0.75 | 50 | empty |
| 2 | 123 | 0.53 | 0.82 | 28 | empty |
| 3 | 101 | 0.39 | 0.75 | 18 | empty |
| 4 | 73 | 0.30 | 0.73 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1562 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 672 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 455 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 1IQD · Human factor VIII C2 domain complexed to human monoclonal BO2C11 Fab. · the same entry in another collection · chain A against A, TM-score 1.00
- P00451 · AlphaFold monomer V2.0 prediction for coagulation factor VIII (P00451) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00451
- Elsewhere: RCSB PDB 1IQD · PDBe 1IQD · UniProt P00451
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