Research workbench

URATE OXIDASE DI-AZIDE complex

Analyse URATE OXIDASE DI-AZIDE complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4PUV
Type: protein
Length: 295 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.3
Source: Aspergillus flavus
Molecule: Uricase
EC: 1.7.3.3
UniProt: Q00511
Ligands: NA, AZI
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · resolution 1.3 · 1 distinct chain · 28% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uricase (EC 1.7.3.3)	protein	295	28% helix, 39% strand	Q00511

Ligands and binding sites

NA · Sodium ion · metal · chains A
AZI · Azide ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	218	0.57	0.79	24	empty
2	179	0.47	0.75	25	AZI

Compared structures

4PUV · Urate oxidase di-azide complex · the same entry in another collection · chain A against A, TM-score 1.00
Q00511 · AlphaFold monomer V2.0 prediction for uricase (Q00511) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00511
Elsewhere: RCSB PDB 4PUV · PDBe 4PUV · UniProt Q00511

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