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Crystal Structure of Biotin Carboxylase from Haemophilus influenzae in Complex with ADP and Phosphate
Analyse Crystal Structure of Biotin Carboxylase from Haemophilus influenzae in Complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MV1
- Type
- protein
- Length
- 430 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.91
- Source
- Haemophilus influenzae
- Molecule
- Biotin carboxylase
- EC
- 6.3.4.14, 6.4.1.2
- UniProt
- P43873
- Ligands
- ADP, PO4
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · resolution 1.91 · 1 distinct chain · 37% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Biotin carboxylase (EC 6.3.4.14, 6.4.1.2) | protein | 430 | 37% helix, 27% strand | P43873 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- PO4 · Phosphate ion · ion · chains A
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 590 | 0.68 | 0.77 | 54 | PO4, ADP |
Compared structures
- 4MV1 · Crystal structure of biotin carboxylase from haemophilus influenzae in complex with ADP… · the same entry in another collection · chain A against A, TM-score 1.00
- P43873 · AlphaFold monomer V2.0 prediction for biotin carboxylase (P43873) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43873
- Elsewhere: RCSB PDB 4MV1 · PDBe 4MV1 · UniProt P43873
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