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AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase ZNRF3 (Q9ULT6)

Analyse AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase ZNRF3 (Q9ULT6) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession
Q9ULT6
Type
protein
Length
936 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0xb3371708538E23D29A3Bd51b2aAF1CBe50bF8768
Molecule
E3 ubiquitin-protein ligase ZNRF3
UniProt
Q9ULT6
Pockets
1 · best druggability 0.45

Structure

1 distinct chain · 11% helix, 8% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AE3 ubiquitin-protein ligase ZNRF3protein93611% helix, 8% strandQ9ULT6

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1650.450.8316empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

  • 8XFS · LGR4-RSPO2-ZNRF3 RING domain (1:2:2) · an experimental structure of the same protein · chain A against E, TM-score 0.17
  • 8XFP · the pentamerA complex of LGR4-RSPO2-ZNRF3(delta RING) · an experimental structure of the same protein · chain A against C, TM-score 0.16
  • 8G4Y · Structure of ZNRF3 ECD bound to peptide MK1-3.6.10 · an experimental structure of the same protein · chain A against A, TM-score 0.16
  • 8Y69 · LGR4-RSPO2-ZNRF3 (2:2:2) · an experimental structure of the same protein · chain A against C, TM-score 0.16
  • 8XFT · LGR4-RSPO2-ZNRF3(1:1:1) · an experimental structure of the same protein · chain A against C, TM-score 0.15

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