UniProt Q9ULT6
E3 ubiquitin-protein ligase ZNRF3 (Q9ULT6)
E3 ubiquitin-protein ligase ZNRF3 (UniProt Q9ULT6), EC 2.3.2.27: 3 experimental structures and 1 predicted model on GenesisL1, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9ULT6
- Protein
- E3 ubiquitin-protein ligase ZNRF3
- EC
- 2.3.2.27
- Experimental structures
- 3
- Predicted models
- 1
- Pockets
- 23 · 2 records with a druggable one
Structures
4 records of Q9ULT6 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8G4Y | Structure of ZNRF3 ECD bound to peptide MK1-3.6.10 | x-ray diffraction | A | — | 2 (best 0.45) |
| 8XFP | the pentamerA complex of LGR4-RSPO2-ZNRF3(delta RING) | electron microscopy | C, H | — | 10 (best 0.81) |
| 8XFS | LGR4-RSPO2-ZNRF3 RING domain (1:2:2) | electron microscopy | C, E | — | 10 (best 0.80) |
| Q9ULT6 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase ZNRF3 (Q9ULT6) | predicted | A | — | 1 (best 0.45) |
Experiment against prediction
- 8XFP chain H against the predicted model Q9ULT6: TM-score 0.94, RMSD 1.30 Å
- 8G4Y chain A against the predicted model Q9ULT6: TM-score 0.89, RMSD 2.33 Å
- 8XFS chain C against the predicted model Q9ULT6: TM-score 0.81, RMSD 2.17 Å
- 8XFP chain C against the predicted model Q9ULT6: TM-score 0.81, RMSD 1.84 Å
- 8XFS chain E against the predicted model Q9ULT6: TM-score 0.80, RMSD 2.61 Å
Elsewhere
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