Research workbench
AlphaFold monomer V2.0 prediction for cullin-associated NEDD8-dissociated protein 1 (Q86VP6)
Analyse AlphaFold monomer V2.0 prediction for cullin-associated NEDD8-dissociated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q86VP6
- Type
- protein
- Length
- 1,230 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x797F1A94123126ED748f3C0fcedDCf457AB502aa
- Molecule
- Cullin-associated NEDD8-dissociated protein 1
- UniProt
- Q86VP6
- Pockets
- 7 · best druggability 0.65
Structure
1 distinct chain · 75% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cullin-associated NEDD8-dissociated protein 1 | protein | 1230 | 75% helix, 1% strand | Q86VP6 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 231 | 0.65 | 0.83 | 33 | empty |
| 2 | 387 | 0.63 | 0.78 | 52 | empty |
| 3 | 97 | 0.43 | 0.79 | 19 | empty |
| 4 | 76 | 0.42 | 0.80 | 16 | empty |
| 5 | 119 | 0.37 | 0.74 | 21 | empty |
Compared structures
- 1U6G · Crystal structure of the CAND1-CUL1-ROC1 complex · an experimental structure of the same protein · chain A against C, TM-score 0.80
- 1U6G · Crystal Structure of The Cand1-Cul1-Roc1 Complex · an experimental structure of the same protein · chain A against C, TM-score 0.80
- 8OR0 · CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 · an experimental structure of the same protein · chain A against C, TM-score 0.80
- 7Z8R · CAND1-CUL1-RBX1 · an experimental structure of the same protein · chain A against D, TM-score 0.79
- 7Z8V · CAND1-SCF-SKP2 (SKP1deldel) CAND1 engaged SCF rocked · an experimental structure of the same protein · chain A against D, TM-score 0.79
- 7Z8T · CAND1-SCF-SKP2 CAND1 engaged SCF rocked · an experimental structure of the same protein · chain A against D, TM-score 0.79
- 8CDK · CAND1 b-hairpin++-SCF-SKP2 CAND1 partly engaged SCF partly rocked · an experimental structure of the same protein · chain A against D, TM-score 0.79
- 7ZBZ · CAND1 delhairpin-SCF-SKP2 CAND1 partly engaged SCF partly rocked · an experimental structure of the same protein · chain A against D, TM-score 0.79
- 8OR3 · CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 · an experimental structure of the same protein · chain A against C, TM-score 0.78
- 8OR2 · CAND1-CUL1-RBX1-DCNL1 · an experimental structure of the same protein · chain A against C, TM-score 0.78
- 4A0C · Structure of the CAND1-CUL4B-RBX1 complex · an experimental structure of the same protein · chain A against B, TM-score 0.76
- 4A0C · Structure of the CAND1-CUL4B-RBX1 complex · an experimental structure of the same protein · chain A against B, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86VP6
- Elsewhere: UniProt Q86VP6 · AlphaFold DB Q86VP6
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