Research workbench
AlphaFold monomer V2.0 prediction for werner syndrome ATP-dependent helicase (Q14191)
Analyse AlphaFold monomer V2.0 prediction for werner syndrome ATP-dependent helicase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q14191
- Type
- protein
- Length
- 1,432 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x72360902aC5Fc3aBA773d5596750fe4DBf522e8d
- Molecule
- Werner syndrome ATP-dependent helicase
- UniProt
- Q14191
- Pockets
- 12 · best druggability 0.80
Structure
1 distinct chain · 39% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Werner syndrome ATP-dependent helicase | protein | 1432 | 39% helix, 8% strand | Q14191 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 594 | 0.80 | 0.86 | 56 | empty |
| 2 | 713 | 0.68 | 0.76 | 66 | empty |
| 3 | 436 | 0.66 | 0.78 | 51 | empty |
| 4 | 232 | 0.58 | 0.79 | 28 | empty |
| 5 | 87 | 0.47 | 0.81 | 15 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6YHR · Crystal structure of werner syndrome helicase · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 6YHR · Crystal structure of Werner syndrome helicase · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 7GQS · Crystal Structure of Werner helicase fragment 517-945 in complex with ADP · an experimental structure of the same protein · chain A against A, TM-score 0.29
- 7GQT · Crystal Structure of Werner helicase fragment 517-945 in complex with ATP · an experimental structure of the same protein · chain A against A, TM-score 0.28
- 8YLE · Crystal structure of Werner syndrome helicase complexed with AMP-PCP · an experimental structure of the same protein · chain A against A, TM-score 0.28
- 7GQU · Crystal Structure of Werner helicase fragment 517-945 in covalent complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.28
- 8PFP · Crystal structure of WRN helicase domain in complex with ATPgammaS · an experimental structure of the same protein · chain A against A, TM-score 0.26
- 8PFL · Crystal structure of WRN helicase domain in complex with 3 · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 8PFO · Crystal structure of WRN helicase domain in complex with HRO761 · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 2FC0 · Wrn exonuclease, mn dgmp complex · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 2FC0 · WRN exonuclease, Mn dGMP complex · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 2FBY · Wrn exonuclease, eu complex · an experimental structure of the same protein · chain A against A, TM-score 0.13
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14191
- Elsewhere: UniProt Q14191 · AlphaFold DB Q14191
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.