UniProt Q14191
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Q14191)
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (UniProt Q14191), EC 3.1.-.-, 3.6.4.12: 27 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 26 pockets. Binding sites, druggability and…
- UniProt
- Q14191
- Protein
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- EC
- 3.1.-.-, 3.6.4.12
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 26 · 7 records with a druggable one
Structures
28 records of Q14191 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AXL | Solution structure of a multifunctional DNA- and protein-binding domain of human Werner syndrome… | solution nmr | A | — | — |
| 2AXL | Solution structure of a multifunctional DNA- and protein-binding domain of human werner syndrome… | solution nmr | A | — | — |
| 2DGZ | Solution structure of the Helicase and RNase D C-terminal domain in Werner syndrome ATP-dependent… | solution nmr | A | — | — |
| 2DGZ | Solution structure of the helicase and RNase D C-terminal domain in werner syndrome ATP-dependent… | solution nmr | A | — | — |
| 2E1E | Crystal structure of the HRDC Domain of Human Werner Syndrome Protein, WRN | x-ray diffraction | A | — | — |
| 2E1E | Crystal structure of the hrdc domain of human werner syndrome protein, wrn | x-ray diffraction | A | — | — |
| 2E1F | Crystal structure of the HRDC Domain of Human Werner Syndrome Protein, WRN | x-ray diffraction | A | — | — |
| 2E1F | Crystal structure of the hrdc domain of human werner syndrome protein, wrn | x-ray diffraction | A | — | — |
| 2FBT | WRN exonuclease | x-ray diffraction | A | — | — |
| 2FBT | Wrn exonuclease | x-ray diffraction | A | — | — |
| 2FBV | WRN exonuclease, Mn complex | x-ray diffraction | A | — | — |
| 2FBV | Wrn exonuclease, mn complex | x-ray diffraction | A | — | — |
| 2FBX | WRN exonuclease, Mg complex | x-ray diffraction | A | — | — |
| 2FBX | Wrn exonuclease, mg complex | x-ray diffraction | A | — | — |
| 2FBY | WRN exonuclease, Eu complex | x-ray diffraction | A | — | — |
| 2FBY | Wrn exonuclease, eu complex | x-ray diffraction | A | — | — |
| 2FC0 | WRN exonuclease, Mn dGMP complex | x-ray diffraction | A | — | — |
| 2FC0 | Wrn exonuclease, mn dgmp complex | x-ray diffraction | A | — | — |
| 3AAF | Structure of WRN RQC domain bound to double-stranded DNA | x-ray diffraction | A, B | — | — |
| 3AAF | Structure of wrn rqc domain bound to double-stranded DNA | x-ray diffraction | A, B | — | — |
| 6YHR | Crystal structure of Werner syndrome helicase | x-ray diffraction | A | ADP, ZN | 5 (best 0.79) |
| 6YHR | Crystal structure of werner syndrome helicase | x-ray diffraction | A | ADP, ZN | — |
| 7GQS | Crystal Structure of Werner helicase fragment 517-945 in complex with ADP | x-ray diffraction | A | ADP, CD, CL | 1 (best 0.76) |
| 7GQT | Crystal Structure of Werner helicase fragment 517-945 in complex with ATP | x-ray diffraction | A | ZN, ATP, MG | 3 (best 0.71) |
| 7GQU | Crystal Structure of Werner helicase fragment 517-945 in covalent complex with… | x-ray diffraction | A | ZN, ADP, X1L, NA | 2 (best 0.81) |
| 8PFP | Crystal structure of WRN helicase domain in complex with ATPgammaS | x-ray diffraction | A | ZN, AGS | 2 (best 0.77) |
| 8YLE | Crystal structure of Werner syndrome helicase complexed with AMP-PCP | x-ray diffraction | A | ACP, ZN | 1 (best 0.78) |
| Q14191 | AlphaFold monomer V2.0 prediction for werner syndrome ATP-dependent helicase (Q14191) | predicted | A | — | 12 (best 0.80) |
Ligands
- ZN · Zinc ion · in 6 records
- ADP · Adenosine-5'-diphosphate · in 4 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 1 record
- AGS · Phosphothiophosphoric acid-adenylate ester · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- CD · Cadmium ion · in 1 record
- CL · Chloride ion · in 1 record
- MG · Magnesium ion · in 1 record
- NA · Sodium ion · in 1 record
- X1L · N-[(1S)-1-cyclopropyl-3-(methanesulfonyl)propyl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide · in 1 record
Experiment against prediction
- 3AAF chain A against the predicted model Q14191: TM-score 0.98, RMSD 0.65 Å
- 3AAF chain A against the predicted model Q14191: TM-score 0.98, RMSD 0.65 Å
- 2E1F chain A against the predicted model Q14191: TM-score 0.96, RMSD 1.11 Å
- 2E1F chain A against the predicted model Q14191: TM-score 0.96, RMSD 1.11 Å
- 6YHR chain A against the predicted model Q14191: TM-score 0.95, RMSD 1.94 Å
- 6YHR chain A against the predicted model Q14191: TM-score 0.95, RMSD 1.94 Å
- 2E1E chain A against the predicted model Q14191: TM-score 0.95, RMSD 1.17 Å
- 2E1E chain A against the predicted model Q14191: TM-score 0.95, RMSD 1.17 Å
- 2FC0 chain A against the predicted model Q14191: TM-score 0.95, RMSD 1.46 Å
- 2FC0 chain A against the predicted model Q14191: TM-score 0.95, RMSD 1.46 Å
Elsewhere
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