Research workbench
AlphaFold monomer V2.0 prediction for chromaffin granule amine transporter (P54219)
Analyse AlphaFold monomer V2.0 prediction for chromaffin granule amine transporter… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P54219
- Type
- protein
- Length
- 525 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xDfA35f0a55525d00318dd861772da3C33F137075
- Molecule
- Chromaffin granule amine transporter
- UniProt
- P54219
- Pockets
- 4 · best druggability 0.81
Structure
1 distinct chain · 71% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromaffin granule amine transporter | protein | 525 | 71% helix, 2% strand | P54219 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 576 | 0.81 | 0.86 | 70 | empty |
| 2 | 154 | 0.47 | 0.77 | 26 | empty |
| 3 | 108 | 0.36 | 0.74 | 15 | empty |
| 4 | 70 | 0.29 | 0.73 | 17 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 8TGI · VMAT1 dimer with dopamine and reserpine · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 8TGN · VMAT1 dimer with serotonin and reserpine · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 8TGK · VMAT1 dimer with histamine and reserpine · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 8TGH · VMAT1 dimer with amphetamine and reserpine · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 8TGG · VMAT1 dimer with MPP+ and reserpine · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 8TGL · VMAT1 dimer with norepinephrine and reserpine · an experimental structure of the same protein · chain A against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54219
- Elsewhere: UniProt P54219 · AlphaFold DB P54219
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