UniProt P54219
Chromaffin granule amine transporter (P54219)
Chromaffin granule amine transporter (UniProt P54219): 4 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P54219
- Protein
- Chromaffin granule amine transporter
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 21 · 5 records with a druggable one
Structures
5 records of P54219 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8TGG | VMAT1 dimer with MPP+ and reserpine | electron microscopy | A, B | WRF, YHR | 4 (best 0.81) |
| 8TGH | VMAT1 dimer with amphetamine and reserpine | electron microscopy | A, B | 1WE, YHR | 3 (best 0.81) |
| 8TGI | VMAT1 dimer with dopamine and reserpine | electron microscopy | A, B | LDP, YHR | 4 (best 0.82) |
| 8TGL | VMAT1 dimer with norepinephrine and reserpine | electron microscopy | A, B | LNR, YHR | 6 (best 0.82) |
| P54219 | AlphaFold monomer V2.0 prediction for chromaffin granule amine transporter (P54219) | predicted | A | — | 4 (best 0.81) |
Ligands
Experiment against prediction
- 8TGI chain A against the predicted model P54219: TM-score 0.98, RMSD 1.02 Å
- 8TGH chain A against the predicted model P54219: TM-score 0.98, RMSD 1.04 Å
- 8TGL chain A against the predicted model P54219: TM-score 0.98, RMSD 1.07 Å
- 8TGG chain A against the predicted model P54219: TM-score 0.98, RMSD 1.09 Å
- 8TGH chain B against the predicted model P54219: TM-score 0.85, RMSD 3.27 Å
- 8TGG chain B against the predicted model P54219: TM-score 0.85, RMSD 3.28 Å
- 8TGI chain B against the predicted model P54219: TM-score 0.85, RMSD 3.31 Å
- 8TGL chain B against the predicted model P54219: TM-score 0.84, RMSD 3.26 Å
Elsewhere
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