Research workbench
AlphaFold monomer V2.0 prediction for vascular endothelial growth factor receptor 1 (P17948)
Analyse AlphaFold monomer V2.0 prediction for vascular endothelial growth factor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P17948
- Type
- protein
- Length
- 1,338 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x71B2F470412030B8E2e004257dbF65C5d54BF3a8
- Molecule
- Vascular endothelial growth factor receptor 1
- UniProt
- P17948
- Pockets
- 10 · best druggability 0.72
Structure
1 distinct chain · 14% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vascular endothelial growth factor receptor 1 | protein | 1338 | 14% helix, 34% strand | P17948 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 450 | 0.72 | 0.82 | 49 | empty |
| 2 | 284 | 0.62 | 0.80 | 40 | empty |
| 3 | 128 | 0.50 | 0.80 | 26 | empty |
| 4 | 63 | 0.46 | 0.83 | 10 | empty |
| 5 | 166 | 0.45 | 0.75 | 23 | empty |
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 5T89 · Crystal structure of VEGF-a in complex with vegfr-1 domains D1-6 · an experimental structure of the same protein · chain A against Y, TM-score 0.39
- 3HNG · Crystal structure of VEGFR1 in complex with N-(4-chlorophenyl)-2… · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 3HNG · Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amin… · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 1QSV · The VEGF-binding domain of flt-1, 20 NMR structures · an experimental structure of the same protein · chain A against A, TM-score 0.07
- 1QSV · The VEGF-binding domain of flt-1, 20 NMR structures · an experimental structure of the same protein · chain A against A, TM-score 0.07
- 1QSZ · The VEGF-binding domain of flt-1 (minimized mean) · an experimental structure of the same protein · chain A against A, TM-score 0.07
- 1QSZ · The VEGF-binding domain of flt-1 (minimized mean) · an experimental structure of the same protein · chain A against A, TM-score 0.07
- 2XAC · Structural insights into the binding of VEGF-B by vegfr-1D2: recognition and specificity · an experimental structure of the same protein · chain A against C, TM-score 0.07
- 2XAC · Structural Insights into the Binding of VEGF-B by VEGFR-1D2: Recognition and Specificity · an experimental structure of the same protein · chain A against C, TM-score 0.07
- 5ABD · Crystal structure of vegfr-1 domain 2 in presence of cu · an experimental structure of the same protein · chain A against E, TM-score 0.07
- 5ABD · Crystal structure of vegfr-1 domain 2 in presence of cu · an experimental structure of the same protein · chain A against E, TM-score 0.07
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17948
- Elsewhere: UniProt P17948 · AlphaFold DB P17948
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