UniProt P17948
Vascular endothelial growth factor receptor 1 (P17948)
Vascular endothelial growth factor receptor 1 (UniProt P17948), EC 2.7.10.1: 21 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 12 pockets. Binding sites, druggability and experiment against…
- UniProt
- P17948
- Protein
- Vascular endothelial growth factor receptor 1
- EC
- 2.7.10.1
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 12 · 2 records with a druggable one
Structures
22 records of P17948 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FLT | VEGF in complex with domain 2 of the flt-1 receptor | x-ray diffraction | X, Y | — | — |
| 1FLT | VEGF in complex with domain 2 of the flt-1 receptor | x-ray diffraction | X, Y | — | — |
| 1QSV | The VEGF-binding domain of flt-1, 20 NMR structures | solution nmr | A | — | — |
| 1QSV | The VEGF-binding domain of flt-1, 20 NMR structures | solution nmr | A | — | — |
| 1QSZ | The VEGF-binding domain of flt-1 (minimized mean) | solution nmr | A | — | — |
| 1QSZ | The VEGF-binding domain of flt-1 (minimized mean) | solution nmr | A | — | — |
| 1QTY | Vascular endothelial growth factor in complex with domain 2 of the flt-1 receptor | x-ray diffraction | X, Y, T, U | — | — |
| 1QTY | Vascular endothelial growth factor in complex with domain 2 of the flt-1 receptor | x-ray diffraction | X, Y, T, U | — | — |
| 1RV6 | Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1 | x-ray diffraction | X, Y | — | — |
| 1RV6 | Crystal structure of plgf in complex with domain 2 of VEGFR1 | x-ray diffraction | X, Y | — | — |
| 2XAC | Structural Insights into the Binding of VEGF-B by VEGFR-1D2: Recognition and Specificity | x-ray diffraction | C, X | — | — |
| 2XAC | Structural insights into the binding of VEGF-B by vegfr-1D2: recognition and specificity | x-ray diffraction | C, X | — | — |
| 3HNG | Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamid… | x-ray diffraction | A | — | — |
| 3HNG | Crystal structure of VEGFR1 in complex with N-(4-chlorophenyl)-2… | x-ray diffraction | A | — | — |
| 4CKV | Crystal structure of VEGFR-1 domain 2 in presence of Zn | x-ray diffraction | X | — | — |
| 4CKV | Crystal structure of vegfr-1 domain 2 in presence of zn | x-ray diffraction | X | — | — |
| 4CL7 | Crystal structure of VEGFR-1 domain 2 in presence of Cobalt | x-ray diffraction | A, B, C, D | — | — |
| 4CL7 | Crystal structure of vegfr-1 domain 2 in presence of cobalt | x-ray diffraction | A, B, C, D | — | — |
| 5ABD | Crystal structure of vegfr-1 domain 2 in presence of cu | x-ray diffraction | E, I, X | NA, SO4, CU | 2 (best 0.67) |
| 5ABD | Crystal structure of vegfr-1 domain 2 in presence of cu | x-ray diffraction | E, I, X | — | — |
| 5T89 | Crystal structure of VEGF-a in complex with vegfr-1 domains D1-6 | x-ray diffraction | X, Y | NAG | — |
| P17948 | AlphaFold monomer V2.0 prediction for vascular endothelial growth factor receptor 1 (P17948) | predicted | A | — | 10 (best 0.72) |
Ligands
Experiment against prediction
- 1RV6 chain X against the predicted model P17948: TM-score 0.98, RMSD 0.45 Å
- 1RV6 chain X against the predicted model P17948: TM-score 0.98, RMSD 0.45 Å
- 4CL7 chain A against the predicted model P17948: TM-score 0.98, RMSD 0.47 Å
- 4CL7 chain A against the predicted model P17948: TM-score 0.98, RMSD 0.47 Å
- 1QTY chain X against the predicted model P17948: TM-score 0.98, RMSD 0.50 Å
- 1QTY chain X against the predicted model P17948: TM-score 0.98, RMSD 0.50 Å
- 4CKV chain X against the predicted model P17948: TM-score 0.97, RMSD 0.64 Å
- 4CKV chain X against the predicted model P17948: TM-score 0.97, RMSD 0.64 Å
- 5ABD chain I against the predicted model P17948: TM-score 0.97, RMSD 0.67 Å
- 5ABD chain I against the predicted model P17948: TM-score 0.97, RMSD 0.67 Å
Elsewhere
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