AlphaFold monomer V2.0 prediction for uromodulin (P07911)

Structure

1 distinct chain · 5% helix, 41% strand (DSSP).

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 24 disulfide (disulfide).

Compared structures

• 4WRN · Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein · an experimental structure of the same protein · chain A against A, TM-score 0.48
• 4WRN · Crystal structure of the polymerization region of human UROMODULIN/TAMM-horsfall protein · an experimental structure of the same protein · chain A against A, TM-score 0.48
• 7PFP · Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein… · an experimental structure of the same protein · chain A against A, TM-score 0.33
• 7PFP · Full-length cryo-EM structure of the native human uromodulin (umod) /tamm-horsfall… · an experimental structure of the same protein · chain A against A, TM-score 0.33
• 7Q3N · Cryo-EM of the complex between human uromodulin (UMOD)/TAMM-horsfall protein (thp) and… · an experimental structure of the same protein · chain A against U, TM-score 0.33
• 7Q3N · Cryo-EM of the complex between human uromodulin (UMOD)/Tamm-Horsfall protein (THP) and… · an experimental structure of the same protein · chain A against U, TM-score 0.33
• 6TQK · Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament. · an experimental structure of the same protein · chain A against A, TM-score 0.25
• 6TQK · Cryo-EM of native human uromodulin (UMOD)/TAMM-horsfall protein (thp) filament. · an experimental structure of the same protein · chain A against A, TM-score 0.25

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P07911
• Elsewhere: UniProt P07911 · AlphaFold DB P07911