UniProt P07911
Uromodulin (P07911)
Uromodulin (UniProt P07911): 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07911
- Protein
- Uromodulin
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 2 · 0 records with a druggable one
Structures
9 records of P07911 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4WRN | Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein | x-ray diffraction | A, B | — | — |
| 4WRN | Crystal structure of the polymerization region of human UROMODULIN/TAMM-horsfall protein | x-ray diffraction | A, B | — | — |
| 6TQK | Cryo-EM of native human uromodulin (UMOD)/TAMM-horsfall protein (thp) filament. | electron microscopy | A, B, C | NAG | — |
| 6TQL | Cryo-EM of elastase-treated human uromodulin (UMOD)/TAMM-horsfall protein (thp) filament | electron microscopy | A, B, C | NAG | — |
| 6ZS5 | 3.5 a cryo-EM structure of human uromodulin filament core | electron microscopy | A, D | NAG, MAN | — |
| 6ZYA | Extended human uromodulin filament core at 3.5 a resolution | electron microscopy | A | NAG | — |
| 7PFP | Full-length cryo-EM structure of the native human uromodulin (umod) /tamm-horsfall protein (thp)… | electron microscopy | A, B, C | NAG, FUC, BMA, GAL, MAN | — |
| 7Q3N | Cryo-EM of the complex between human uromodulin (UMOD)/TAMM-horsfall protein (thp) and the fimh… | electron microscopy | U | NAG, FUC, GAL, BMA, MAN | — |
| P07911 | AlphaFold monomer V2.0 prediction for uromodulin (P07911) | predicted | A | — | 2 (best 0.48) |
Ligands
Experiment against prediction
- 6ZS5 chain D against the predicted model P07911: TM-score 0.88, RMSD 1.36 Å
- 6TQL chain B against the predicted model P07911: TM-score 0.87, RMSD 1.64 Å
- 6TQK chain B against the predicted model P07911: TM-score 0.87, RMSD 1.97 Å
- 7PFP chain B against the predicted model P07911: TM-score 0.86, RMSD 2.12 Å
- 6ZS5 chain A against the predicted model P07911: TM-score 0.85, RMSD 1.80 Å
- 6TQL chain C against the predicted model P07911: TM-score 0.81, RMSD 2.72 Å
- 6TQK chain C against the predicted model P07911: TM-score 0.80, RMSD 2.84 Å
- 7Q3N chain U against the predicted model P07911: TM-score 0.68, RMSD 3.51 Å
- 6TQK chain A against the predicted model P07911: TM-score 0.52, RMSD 3.54 Å
- 6TQL chain A against the predicted model P07911: TM-score 0.51, RMSD 3.04 Å
Elsewhere
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