Research workbench
AlphaFold monomer V2.0 prediction for urokinase-type plasminogen activator (P00749)
Analyse AlphaFold monomer V2.0 prediction for urokinase-type plasminogen activator… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P00749
- Type
- protein
- Length
- 431 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x2E7853F600caf0B93109Bd82A4F48D84b36cE0c4
- Molecule
- Urokinase-type plasminogen activator
- UniProt
- P00749
- Pockets
- 4 · best druggability 0.58
Structure
1 distinct chain · 8% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Urokinase-type plasminogen activator | protein | 431 | 8% helix, 28% strand | P00749 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 382 | 0.58 | 0.75 | 40 | empty |
| 2 | 96 | 0.54 | 0.85 | 20 | empty |
| 3 | 108 | 0.42 | 0.77 | 22 | empty |
| 4 | 118 | 0.41 | 0.76 | 27 | empty |
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 2VNT · Urokinase-Type Plasminogen Activator Inhibitor Complex with a 1-(7… · an experimental structure of the same protein · chain A against A, TM-score 0.58
- 6NMB · Tranexamic Acid is an Active Site Inhibitor of Urokinase Plasminogen Activator · an experimental structure of the same protein · chain A against B, TM-score 0.58
- 1C5Y · Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar… · an experimental structure of the same protein · chain A against B, TM-score 0.56
- 1C5X · Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar… · an experimental structure of the same protein · chain A against B, TM-score 0.56
- 1C5W · Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar… · an experimental structure of the same protein · chain A against B, TM-score 0.56
- 1W11 · Urokinase type plasminogen activator · an experimental structure of the same protein · chain A against U, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00749
- Elsewhere: UniProt P00749 · AlphaFold DB P00749
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