UniProt P00749
Urokinase-type plasminogen activator (P00749)
Urokinase-type plasminogen activator (UniProt P00749), EC 3.4.21.73: 271 experimental structures and 1 predicted model on GenesisL1, 25 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P00749
- Protein
- Urokinase-type plasminogen activator
- EC
- 3.4.21.73
- Experimental structures
- 271
- Predicted models
- 1
- Ligands
- 25
- Pockets
- 26 · 2 records with a druggable one
Structures
272 records of P00749 in the MolNFT archive: 271 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1C5W | Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar inhibitor of… | x-ray diffraction | A, B | — | — |
| 1C5W | Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of… | x-ray diffraction | A, B | — | — |
| 1C5X | Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar inhibitor of… | x-ray diffraction | A, B | — | — |
| 1C5X | Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of… | x-ray diffraction | A, B | — | — |
| 1C5Y | Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar inhibitor of… | x-ray diffraction | A, B | — | — |
| 1C5Y | Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of… | x-ray diffraction | A, B | — | — |
| 1C5Z | Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar inhibitor of… | x-ray diffraction | A, B | — | — |
| 1C5Z | Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of… | x-ray diffraction | A, B | — | — |
| 1EJN | Urokinase plasminogen activator B-chain inhibitor complex | x-ray diffraction | A | — | — |
| 1EJN | Urokinase plasminogen activator B-chain inhibitor complex | x-ray diffraction | A | — | — |
| 1F5L | Urokinase plasminogen activator B-chain-amiloride complex | x-ray diffraction | A | — | — |
| 1F5L | Urokinase plasminogen activator B-chain-amiloride complex | x-ray diffraction | A | — | — |
| 1F92 | Urokinase plasminogen activator B chain-uki-1D complex | x-ray diffraction | A | — | — |
| 1F92 | Urokinase plasminogen activator B chain-uki-1D complex | x-ray diffraction | A | — | — |
| 1FV9 | Crystal structure of human microurokinase in complex with 2-amino-5-hydroxy-benzimidazole | x-ray diffraction | A | — | — |
| 1FV9 | Crystal structure of human microurokinase in complex with 2-amino-5- hydroxy-benzimidazole | x-ray diffraction | A | — | — |
| 1GI7 | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | A, B | — | — |
| 1GI7 | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | A, B | — | — |
| 1GI8 | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | A, B | — | — |
| 1GI8 | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | A, B | — | — |
| 1GI9 | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | A, B | — | — |
| 1GI9 | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network… | x-ray diffraction | A, B | — | — |
| 1GJ7 | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJ7 | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJ8 | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJ8 | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJ9 | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJ9 | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJA | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJA | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJB | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJB | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJC | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJC | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJD | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1GJD | Engineering inhibitors highly selective for the S1 sites of SER190 trypsin-like serine protease… | x-ray diffraction | A, B | — | — |
| 1KDU | Sequential 1H NMR assignments and secondary structure of the kringle domain from urokinase | solution nmr | A | — | — |
| 1KDU | Sequential 1H NMR assignments and secondary structure of the kringle domain from urokinase | solution nmr | A | — | — |
| 1LMW | LMW U-PA Structure complexed with EGRCMK (GLU-GLY-ARG Chloromethyl Ketone) | x-ray diffraction | A, B, C, D | — | — |
| 1LMW | Lmw U-pa structure complexed with egrcmk (glu-gly-arg chloromethyl ketone) | x-ray diffraction | A, B, C, D | — | — |
| 1O3P | Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine… | x-ray diffraction | A, B | — | — |
| 1O3P | Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine… | x-ray diffraction | A, B | — | — |
| 1O5A | Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial… | x-ray diffraction | A, B | — | — |
| 1O5A | Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial… | x-ray diffraction | A, B | — | — |
| 1O5B | Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial… | x-ray diffraction | A, B | — | — |
| 1O5B | Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial… | x-ray diffraction | A, B | — | — |
| 1O5C | Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial… | x-ray diffraction | A, B | — | — |
| 1O5C | Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial… | x-ray diffraction | A, B | — | — |
| 1OWD | Substituted 2-Naphthamidine inhibitors of urokinase | x-ray diffraction | A | — | — |
| 1OWD | Substituted 2-naphthamidine inhibitors of urokinase | x-ray diffraction | A | — | — |
| 1OWE | Substituted 2-Naphthamidine inhibitors of urokinase | x-ray diffraction | A | — | — |
| 1OWE | Substituted 2-naphthamidine inhibitors of urokinase | x-ray diffraction | A | — | — |
| 1OWH | Substituted 2-Naphthamidine Inhibitors of Urokinase | x-ray diffraction | A | — | — |
| 1OWH | Substituted 2-naphthamidine inhibitors of urokinase | x-ray diffraction | A | — | — |
| 1OWI | Substituted 2-Naphthamidine Inhibitors of Urokinase | x-ray diffraction | A | — | — |
| 1OWI | Substituted 2-naphthamidine inhibitors of urokinase | x-ray diffraction | A | — | — |
| 1OWJ | Substituted 2-Naphthamidine Inhibitors of Urokinase | x-ray diffraction | A | — | — |
| 1OWJ | Substituted 2-naphthamidine inhibitors of urokinase | x-ray diffraction | A | — | — |
| 1OWK | Substituted 2-Naphthamidine Inhibitors of Urokinase | x-ray diffraction | A | — | — |
| 1OWK | Substituted 2-naphthamidine inhibitors of urokinase | x-ray diffraction | A | — | — |
212 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 19 records
- 50I · 3-azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide · in 4 records
- EAU · 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide · in 3 records
- GBS · 4-guanidinobenzoic acid · in 3 records
- HMX · 3-azanyl-5-(azepan-1-yl)-N-[bis(azanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide · in 3 records
- PZH · 1-(4-bromophenyl)methanamine · in 3 records
- 27I · 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(1-methylpyrazol-4-yl)pyrazine-2-carboxamide · in 2 records
- 32I · 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide · in 2 records
- 7YF · (2R)-N-[2-[[(2S)-5-carbamimidamido-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-5-oxidanylidene-1,2-dihydropyrrole-2-carboxamide · in 2 records
- 94I · 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-pyrimidin-5-yl-pyrazine-2-carboxamide · in 2 records
- 9X9 · 3,5-bis(azanyl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide · in 2 records
- 9XC · 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide · in 2 records
- 9XF · 3,5-bis(azanyl)-6-(1-benzofuran-2-yl)-N-carbamimidoyl-pyrazine-2-carboxamide · in 2 records
- AMH · Trans-4-aminomethylcyclohexane-1-carboxylic acid · in 2 records
- H55 · 3,5-diamino-N-carbamimidoyl-6-(1-methyl-1H-pyrazol-4-yl)pyrazine-2-carboxamide · in 2 records
- NO3 · Nitrate ion · in 2 records
- ZXI · 1-(4-iodophenyl)methanamine · in 2 records
- 09I · 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(4-fluoranyl-1-benzofuran-2-yl)pyrazine-2-carboxamide · in 1 record
- 28I · 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-3-yl)pyrazine-2-carboxamide · in 1 record
- 30I · 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide · in 1 record
- 7R8 · 6-oxidanylnaphthalene-2-carboximidamide · in 1 record
- 7RF · (6-carbamimidoylnaphthalen-2-yl) 4-carbamimidamidobenzoate · in 1 record
- 7YR · (2R)-N-[2-[[(2S)-1-[[4-[bis(oxidanyl) amino]phenyl]amino]-5-carbamimidamido-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-5-oxidanylidene-pyrrolidine-2-carboxamide · in 1 record
- QUE · 3,5,7,3',4'-pentahydroxyflavone · in 1 record
- ZBR · 1,3,5-tris(bromomethyl)benzene · in 1 record
Experiment against prediction
- 6NMB chain B against the predicted model P00749: TM-score 0.98, RMSD 0.95 Å
- 6NMB chain A against the predicted model P00749: TM-score 0.98, RMSD 0.97 Å
- 1F5L chain A against the predicted model P00749: TM-score 0.98, RMSD 0.98 Å
- 3KGP chain A against the predicted model P00749: TM-score 0.98, RMSD 0.98 Å
- 6NMB chain C against the predicted model P00749: TM-score 0.98, RMSD 1.00 Å
- 6AG2 chain U against the predicted model P00749: TM-score 0.98, RMSD 1.00 Å
- 3KHV chain A against the predicted model P00749: TM-score 0.98, RMSD 0.99 Å
- 1O5B chain B against the predicted model P00749: TM-score 0.98, RMSD 1.01 Å
- 1GJ7 chain B against the predicted model P00749: TM-score 0.98, RMSD 1.01 Å
- 1GJ9 chain B against the predicted model P00749: TM-score 0.98, RMSD 1.01 Å
Elsewhere
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