Research workbench
AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily M member 4 (Q7TN37)
Analyse AlphaFold monomer V2.0 prediction for transient receptor potential cation… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q7TN37
- Type
- protein
- Length
- 1,213 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x44D50E828c22812996CB99C7F2E0C5EC9933b478
- Molecule
- Transient receptor potential cation channel subfamily M member 4
- UniProt
- Q7TN37
- Pockets
- 16 · best druggability 0.78
Structure
1 distinct chain · 56% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transient receptor potential cation channel subfamily M member 4 | protein | 1213 | 56% helix, 8% strand | Q7TN37 |
Pockets
16 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1052 | 0.78 | 0.80 | 91 | empty |
| 2 | 131 | 0.77 | 0.95 | 32 | empty |
| 3 | 314 | 0.68 | 0.83 | 40 | empty |
| 4 | 386 | 0.64 | 0.78 | 43 | empty |
| 5 | 305 | 0.56 | 0.77 | 44 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6BCL · cryo-EM structure of TRPM4 in apo state with long coiled coil at 3.5 angstrom resolution · an experimental structure of the same protein · chain A against B, TM-score 0.75
- 6BCL · Cryo-EM structure of TRPM4 in apo state with long coiled coil at 3.5 ångström resolution · an experimental structure of the same protein · chain A against B, TM-score 0.75
- 6BCQ · cryo-EM structure of TRPM4 in ATP bound state with long coiled coil at 3.3 angstrom… · an experimental structure of the same protein · chain A against D, TM-score 0.74
- 6BCQ · Cryo-EM structure of TRPM4 in ATP bound state with long coiled coil at 3.3 ångström… · an experimental structure of the same protein · chain A against B, TM-score 0.74
- 6BCJ · cryo-EM structure of TRPM4 in apo state with short coiled coil at 3.1 angstrom resolution · an experimental structure of the same protein · chain A against C, TM-score 0.73
- 6BCJ · Cryo-EM structure of TRPM4 in apo state with short coiled coil at 3.1 ångström resolution · an experimental structure of the same protein · chain A against B, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7TN37
- Elsewhere: UniProt Q7TN37 · AlphaFold DB Q7TN37
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