Research workbench
AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (P00929)
Analyse AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (P00929) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P00929
- Type
- protein
- Length
- 268 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x025f3b1a898b05AD2731bE6Ab72687b5920c4A3F
- Molecule
- Tryptophan synthase alpha chain
- UniProt
- P00929
- Pockets
- 2 · best druggability 0.68
Structure
1 distinct chain · 49% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophan synthase alpha chain | protein | 268 | 49% helix, 15% strand | P00929 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 278 | 0.68 | 0.83 | 59 | empty |
| 2 | 61 | 0.35 | 0.77 | 19 | empty |
Compared structures
- 4HPX · Crystal structure of Tryptophan Synthase at 1.65 A resolution in complex with alpha… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 7KA1 · 1.60 Angstrom resolution crystal structure of the beta-Q114A mutant Tryptophan Synthase… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 6DZO · Crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-Q114A with… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 6VNT · Tryptophan synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-ami… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 7JTT · The external aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 7JHW · The internal aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 6C73 · Tryptophan synthase Q114A mutant (internal aldimine state) in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 4HPJ · Crystal structure of Tryptophan Synthase at 1.45 A resolution in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 7L1H · The aminoacrylate form of the wild-type Salmonella typhimurium Tryptophan Synthase in… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 4HN4 · Tryptophan synthase in complex with alpha aminoacrylate E(A-A) form and the F9 inhibitor… · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 8B08 · TRYPTOPHAN SYNTHASE - Cryo-trapping by the spitrobot crystal plunger after 30 sec · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 7JMQ · The external aldimine form of the mutant beta-S377A Salmonella thypi tryptophan synthase… · an experimental structure of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00929
- Elsewhere: UniProt P00929 · AlphaFold DB P00929
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