Research workbench

AlphaFold monomer V2.0 prediction for thrombopoietin receptor (Q08351)

Analyse AlphaFold monomer V2.0 prediction for thrombopoietin receptor (Q08351) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: Q08351
Type: protein
Length: 625 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x1141c59a573b52725A219545C456190739feD131
Molecule: Thrombopoietin receptor
UniProt: Q08351
Pockets: 9 · best druggability 0.64

Structure

1 distinct chain · 13% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thrombopoietin receptor	protein	625	13% helix, 32% strand	Q08351

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	470	0.64	0.77	42	empty
2	155	0.61	0.84	28	empty
3	410	0.61	0.76	36	empty
4	112	0.47	0.79	19	empty
5	104	0.39	0.76	22	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

8U18 · Cryo-EM structure of murine Thrombopoietin receptor ectodomain in complex with Tpo · an experimental structure of the same protein · chain A against B, TM-score 0.63
8VU5 · Cryo-EM structure of MPL bound to TPO · an experimental structure of the same protein · chain A against C, TM-score 0.41

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08351
Elsewhere: UniProt Q08351 · AlphaFold DB Q08351

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