Research workbench
AlphaFold monomer V2.0 prediction for two pore calcium channel protein 1 (Q9EQJ0)
Analyse AlphaFold monomer V2.0 prediction for two pore calcium channel protein 1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9EQJ0
- Type
- protein
- Length
- 817 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xc0F878C3f3E2a1874e2A6daC80d429e553DdB0D5
- Molecule
- Two pore calcium channel protein 1
- UniProt
- Q9EQJ0
- Pockets
- 14 · best druggability 0.81
Structure
1 distinct chain · 67% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Two pore calcium channel protein 1 | protein | 817 | 67% helix, 4% strand | Q9EQJ0 |
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 797 | 0.81 | 0.84 | 88 | empty |
| 2 | 518 | 0.74 | 0.82 | 52 | empty |
| 3 | 224 | 0.58 | 0.79 | 27 | empty |
| 4 | 165 | 0.56 | 0.81 | 22 | empty |
| 5 | 145 | 0.50 | 0.79 | 20 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6C96 · Cryo-EM structure of mouse TPC1 channel in the apo state · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 6C96 · Cryo-EM structure of mouse TPC1 channel in the apo state · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 6C9A · Cryo-EM structure of mouse TPC1 channel in the PTDINS(3,5)P2-bound state · an experimental structure of the same protein · chain A against B, TM-score 0.85
- 6C9A · Cryo-EM structure of mouse TPC1 channel in the PtdIns(3,5)P2-bound state · an experimental structure of the same protein · chain A against B, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9EQJ0
- Elsewhere: UniProt Q9EQJ0 · AlphaFold DB Q9EQJ0
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