UniProt Q9EQJ0

Two pore calcium channel protein 1 (Q9EQJ0)

Two pore calcium channel protein 1 (UniProt Q9EQJ0): 4 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 54 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q9EQJ0
Protein: Two pore calcium channel protein 1
Experimental structures: 4
Predicted models: 1
Ligands: 3
Pockets: 54 · 3 records with a druggable one

Structures

5 records of Q9EQJ0 in the MolNFT archive: 4 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6C96	Cryo-EM structure of mouse TPC1 channel in the apo state	electron microscopy	A, B	NAG, NA	20 (best 0.85)
6C96	Cryo-EM structure of mouse TPC1 channel in the apo state	electron microscopy	A, B	NAG	—
6C9A	Cryo-EM structure of mouse TPC1 channel in the PtdIns(3,5)P2-bound state	electron microscopy	B, A	NAG, EUJ	20 (best 0.84)
6C9A	Cryo-EM structure of mouse TPC1 channel in the PTDINS(3,5)P2-bound state	electron microscopy	B, A	NAG, EUJ	—
Q9EQJ0	AlphaFold monomer V2.0 prediction for two pore calcium channel protein 1 (Q9EQJ0)	predicted	A	—	14 (best 0.81)

Ligands

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
EUJ · (2R)-3-{[(S)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate · in 2 records
NA · Sodium ion · in 1 record

Experiment against prediction

6C96 chain A against the predicted model Q9EQJ0: TM-score 0.96, RMSD 1.96 Å
6C96 chain A against the predicted model Q9EQJ0: TM-score 0.96, RMSD 1.96 Å
6C96 chain B against the predicted model Q9EQJ0: TM-score 0.96, RMSD 1.96 Å
6C9A chain B against the predicted model Q9EQJ0: TM-score 0.96, RMSD 2.08 Å
6C9A chain B against the predicted model Q9EQJ0: TM-score 0.96, RMSD 2.08 Å
6C9A chain A against the predicted model Q9EQJ0: TM-score 0.96, RMSD 2.08 Å

Elsewhere

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