Research workbench
AlphaFold monomer V2.0 prediction for angiopoietin-1 receptor (Q02763)
Analyse AlphaFold monomer V2.0 prediction for angiopoietin-1 receptor (Q02763) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q02763
- Type
- protein
- Length
- 1,124 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x913D747815DBa960ca83d1Bb4eD989f5D8b6CB9D
- Molecule
- Angiopoietin-1 receptor
- UniProt
- Q02763
- Pockets
- 11 · best druggability 0.74
Structure
1 distinct chain · 16% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Angiopoietin-1 receptor | protein | 1124 | 16% helix, 35% strand | Q02763 |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 687 | 0.74 | 0.80 | 60 | empty |
| 2 | 508 | 0.73 | 0.82 | 64 | empty |
| 3 | 207 | 0.59 | 0.81 | 24 | empty |
| 4 | 163 | 0.47 | 0.77 | 23 | empty |
| 5 | 215 | 0.46 | 0.74 | 28 | empty |
Modifications
Observed in the structure: 13 disulfide (disulfide).
Compared structures
- 2GY7 · Angiopoietin-2/TIE2 complex crystal structure · an experimental structure of the same protein · chain A against B, TM-score 0.38
- 2GY7 · Angiopoietin-2/Tie2 Complex Crystal Structure · an experimental structure of the same protein · chain A against B, TM-score 0.38
- 2GY5 · Tie2 Ligand-Binding Domain Crystal Structure · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 2GY5 · TIE2 ligand-binding domain crystal structure · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 1FVR · TIE2 kinase domain · an experimental structure of the same protein · chain A against B, TM-score 0.26
- 1FVR · TIE2 kinase domain · an experimental structure of the same protein · chain A against B, TM-score 0.26
- 3L8P · Crystal structure of cytoplasmic kinase domain of TIE2 complexed with inhibitor CEP11207 · an experimental structure of the same protein · chain A against A, TM-score 0.25
- 3L8P · Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207 · an experimental structure of the same protein · chain A against A, TM-score 0.25
- 2WQB · Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.25
- 2WQB · Structure of the TIE2 kinase domain in complex with a thiazolopyrimidine inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02763
- Elsewhere: UniProt Q02763 · AlphaFold DB Q02763
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