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AlphaFold monomer V2.0 prediction for succinate--CoA ligase [ADP/GDP- forming] subunit alpha, mitochondrial (P53597)

Analyse AlphaFold monomer V2.0 prediction for succinate--CoA ligase [ADP/GDP- forming]… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession
P53597
Type
protein
Length
346 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0x7FDF8b382C6a36A8772D1A265E8e480c7DF0A9C1
Molecule
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
UniProt
P53597
Pockets
1 · best druggability 0.46

Structure

1 distinct chain · 33% helix, 19% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ASuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialprotein34633% helix, 19% strandP53597

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11240.460.7830empty

Compared structures

  • 7MST · Phosphorylated human E105Qa GTP-specific succinyl-CoA synthetase complexed with coenzyme A · an experimental structure of the same protein · chain A against A, TM-score 0.88
  • 6WCV · Tartryl-CoA bound to human GTP-specific succinyl-CoA synthetase · an experimental structure of the same protein · chain A against A, TM-score 0.88
  • 6WCV · Tartryl-CoA bound to human GTP-specific succinyl-CoA synthetase · an experimental structure of the same protein · chain A against A, TM-score 0.88
  • 6G4Q · Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1- SUCLA2 · an experimental structure of the same protein · chain A against A, TM-score 0.88
  • 6G4Q · Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2 · an experimental structure of the same protein · chain A against A, TM-score 0.88
  • 7MSR · Human E105Qa GTP-specific succinyl-CoA synthetase complexed with succinyl-phosphate… · an experimental structure of the same protein · chain A against A, TM-score 0.88
  • 7MSS · Human E105Qa GTP-specific succinyl-CoA synthetase complexed with succinate, magnesium ion… · an experimental structure of the same protein · chain A against A, TM-score 0.88
  • 8Z02 · CoA bound to human GTP-specific succinyl-CoA synthetase · an experimental structure of the same protein · chain A against A, TM-score 0.87
  • 8Z03 · Lactate bound to human GTP-specific succinyl-CoA synthetase · an experimental structure of the same protein · chain A against A, TM-score 0.87

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