Research workbench
AlphaFold monomer V2.0 prediction for sterol O-acyltransferase 1 (P35610)
Analyse AlphaFold monomer V2.0 prediction for sterol O-acyltransferase 1 (P35610) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P35610
- Type
- protein
- Length
- 550 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf7Ea384D3b95C3A242403Fdf8e5bA55488D27a6b
- Molecule
- Sterol O-acyltransferase 1
- UniProt
- P35610
- Pockets
- 7 · best druggability 0.85
Structure
1 distinct chain · 67% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sterol O-acyltransferase 1 | protein | 550 | 67% helix, 1% strand | P35610 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 903 | 0.85 | 0.86 | 76 | empty |
| 2 | 244 | 0.65 | 0.81 | 21 | empty |
| 3 | 134 | 0.54 | 0.82 | 18 | empty |
| 4 | 180 | 0.50 | 0.76 | 22 | empty |
| 5 | 146 | 0.44 | 0.76 | 24 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6L47 · Structure of the human sterol O-acyltransferase 1 in complex with ci- 976 · an experimental structure of the same protein · chain A against A, TM-score 0.75
- 6VUM · Structure of nevanimibe-bound human tetrameric ACAT1 · an experimental structure of the same protein · chain A against A, TM-score 0.73
- 6L48 · Structure of the human sterol O-acyltransferase 1 in resting state · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 6P2J · Dimeric structure of ACAT1 · an experimental structure of the same protein · chain A against B, TM-score 0.68
- 6P2J · Dimeric structure of ACAT1 · an experimental structure of the same protein · chain A against B, TM-score 0.68
- 6P2P · Tetrameric structure of ACAT1 · an experimental structure of the same protein · chain A against B, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35610
- Elsewhere: UniProt P35610 · AlphaFold DB P35610
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