UniProt P35610
Sterol O-acyltransferase 1 (P35610)
Sterol O-acyltransferase 1 (UniProt P35610), EC 2.3.1.26: 8 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 57 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P35610
- Protein
- Sterol O-acyltransferase 1
- EC
- 2.3.1.26
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 57 · 4 records with a druggable one
Structures
9 records of P35610 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6L47 | Structure of the human sterol O-acyltransferase 1 in complex with CI-976 | electron microscopy | A, B | E5L, CLR | 13 (best 0.89) |
| 6L47 | Structure of the human sterol O-acyltransferase 1 in complex with ci- 976 | electron microscopy | A, B | E5L, CLR | — |
| 6L48 | Structure of the human sterol O-acyltransferase 1 in resting state | electron microscopy | A, B | CLR | — |
| 6P2J | Dimeric structure of ACAT1 | electron microscopy | A, B | 3VV | 17 (best 0.88) |
| 6P2J | Dimeric structure of ACAT1 | electron microscopy | A, B | 3VV | — |
| 6P2P | Tetrameric structure of ACAT1 | electron microscopy | A, B, C, D | 3VV | 20 (best 0.88) |
| 6P2P | Tetrameric structure of ACAT1 | electron microscopy | A, B, C, D | 3VV | — |
| 6VUM | Structure of nevanimibe-bound human tetrameric ACAT1 | electron microscopy | A, B, C, D | OLA, CLR, ROV, COA, 3VV | — |
| P35610 | AlphaFold monomer V2.0 prediction for sterol O-acyltransferase 1 (P35610) | predicted | A | — | 7 (best 0.85) |
Ligands
- 3VV · S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3, 5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2, 4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) · in 5 records
- CLR · Cholesterol · in 4 records
- E5L · 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide · in 2 records
- COA · Coenzyme A · in 1 record
- OLA · Oleic acid · in 1 record
- ROV · Nevanimibe · in 1 record
Experiment against prediction
- 6L47 chain A against the predicted model P35610: TM-score 0.98, RMSD 1.10 Å
- 6L47 chain A against the predicted model P35610: TM-score 0.98, RMSD 1.10 Å
- 6L47 chain B against the predicted model P35610: TM-score 0.98, RMSD 1.10 Å
- 6VUM chain A against the predicted model P35610: TM-score 0.98, RMSD 1.05 Å
- 6L48 chain A against the predicted model P35610: TM-score 0.98, RMSD 1.08 Å
- 6P2P chain D against the predicted model P35610: TM-score 0.91, RMSD 2.54 Å
- 6P2P chain B against the predicted model P35610: TM-score 0.91, RMSD 2.54 Å
- 6P2P chain B against the predicted model P35610: TM-score 0.91, RMSD 2.54 Å
- 6P2J chain B against the predicted model P35610: TM-score 0.91, RMSD 2.59 Å
- 6P2J chain B against the predicted model P35610: TM-score 0.91, RMSD 2.59 Å
Elsewhere
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