AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETD2 (Q9BYW2)

Structure

1 distinct chain · 9% helix, 3% strand (DSSP).

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 9EH0 · RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, 30 bp upstream · an experimental structure of the same protein · chain A against l, TM-score 0.10
• 5JLB · Crystal structure of SETD2 bound to histone H3.3 K36I peptide · an experimental structure of the same protein · chain A against A, TM-score 0.10
• 5JLB · Crystal structure of SETD2 bound to histone H3.3 K36I peptide · an experimental structure of the same protein · chain A against A, TM-score 0.10
• 6J9J · Crystal structure of SESTD2 in complex with H3.3S31PHK36M peptide · an experimental structure of the same protein · chain A against A, TM-score 0.10
• 6J9J · crystal structure of SESTD2 in complex with H3.3S31phK36M peptide · an experimental structure of the same protein · chain A against A, TM-score 0.10
• 5JJY · Crystal structure of SETD2 bound to histone H3.3 K36M peptide · an experimental structure of the same protein · chain A against A, TM-score 0.10
• 5JJY · Crystal structure of SETD2 bound to histone H3.3 K36M peptide · an experimental structure of the same protein · chain A against A, TM-score 0.10
• 5V22 · Crystal structure of human SETD2 set-domain in complex with H3K36M peptide and sah · an experimental structure of the same protein · chain A against A, TM-score 0.10
• 5V22 · Crystal structure of human SETD2 SET-domain in complex with H3K36M peptide and SAH · an experimental structure of the same protein · chain A against A, TM-score 0.10
• 5V21 · Crystal structure of human SETD2 set-domain in complex with H3K36M peptide and SAM · an experimental structure of the same protein · chain A against A, TM-score 0.10
• 5V21 · Crystal structure of human SETD2 SET-domain in complex with H3K36M peptide and SAM · an experimental structure of the same protein · chain A against A, TM-score 0.10
• 8Q5P · Structure of the lysine methyltransferase SETD2 in complex with a peptide derived from… · an experimental structure of the same protein · chain A against A, TM-score 0.10

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9BYW2
• Elsewhere: UniProt Q9BYW2 · AlphaFold DB Q9BYW2