Research workbench
AlphaFold monomer V2.0 prediction for solute carrier family 40 member 1 (Q9NP59)
Analyse AlphaFold monomer V2.0 prediction for solute carrier family 40 member 1 (Q9NP59) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9NP59
- Type
- protein
- Length
- 571 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xA15011e6fCb04bD3567F1C0feB9323b96C9D1706
- Molecule
- Solute carrier family 40 member 1
- UniProt
- Q9NP59
- Pockets
- 5 · best druggability 0.81
Structure
1 distinct chain · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Solute carrier family 40 member 1 | protein | 571 | 75% helix, 0% strand | Q9NP59 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1136 | 0.81 | 0.82 | 71 | empty |
| 2 | 108 | 0.39 | 0.75 | 18 | empty |
| 3 | 90 | 0.35 | 0.75 | 14 | empty |
| 4 | 51 | 0.33 | 0.78 | 12 | empty |
| 5 | 77 | 0.32 | 0.74 | 15 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 8DL7 · Cryo-EM structure of human ferroportin/slc40 bound to minihepcidin PR73 in nanodisc · an experimental structure of the same protein · chain A against A, TM-score 0.80
- 8DL6 · Cryo-EM structure of human ferroportin/slc40 bound to Ca2+ in nanodisc · an experimental structure of the same protein · chain A against A, TM-score 0.75
- 8DL8 · Cryo-EM structure of human ferroportin/slc40 bound to Co2+ in nanodisc · an experimental structure of the same protein · chain A against A, TM-score 0.75
- 8C03 · Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy12 in… · an experimental structure of the same protein · chain A against A, TM-score 0.73
- 6WBV · Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc · an experimental structure of the same protein · chain A against A, TM-score 0.73
- 6WBV · Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc · an experimental structure of the same protein · chain A against A, TM-score 0.73
- 8C02 · Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded… · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 8BZY · Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in… · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 6W4S · Structure of apo human ferroportin in lipid nanodisc · an experimental structure of the same protein · chain A against F, TM-score 0.71
- 6W4S · Structure of apo human ferroportin in lipid nanodisc · an experimental structure of the same protein · chain A against F, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NP59
- Elsewhere: UniProt Q9NP59 · AlphaFold DB Q9NP59
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