UniProt Q9NP59
Solute carrier family 40 member 1 (Q9NP59)
Solute carrier family 40 member 1 (UniProt Q9NP59), EC 7.-.-.-: 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9NP59
- Protein
- Solute carrier family 40 member 1
- EC
- 7.-.-.-
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 21 · 5 records with a druggable one
Structures
7 records of Q9NP59 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6W4S | Structure of apo human ferroportin in lipid nanodisc | electron microscopy | F | — | 1 (best 0.83) |
| 6W4S | Structure of apo human ferroportin in lipid nanodisc | electron microscopy | F | — | — |
| 6WBV | Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc | electron microscopy | A | AGA, CO | 2 (best 0.89) |
| 6WBV | Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc | electron microscopy | A | AGA, CO | — |
| 8DL6 | Cryo-EM structure of human ferroportin/slc40 bound to Ca2+ in nanodisc | electron microscopy | A | CA | 7 (best 0.84) |
| 8DL7 | Cryo-EM structure of human ferroportin/slc40 bound to minihepcidin PR73 in nanodisc | electron microscopy | A | POV | 6 (best 0.86) |
| Q9NP59 | AlphaFold monomer V2.0 prediction for solute carrier family 40 member 1 (Q9NP59) | predicted | A | — | 5 (best 0.81) |
Ligands
- AGA · (1S)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(pentanoyloxy)methyl]ethyl octanoate · in 2 records
- CO · Cobalt (II) ion · in 2 records
- CA · Calcium ion · in 1 record
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 1 record
Experiment against prediction
- 8DL7 chain A against the predicted model Q9NP59: TM-score 0.97, RMSD 1.60 Å
- 6WBV chain A against the predicted model Q9NP59: TM-score 0.97, RMSD 1.42 Å
- 6WBV chain A against the predicted model Q9NP59: TM-score 0.97, RMSD 1.42 Å
- 8DL6 chain A against the predicted model Q9NP59: TM-score 0.97, RMSD 1.40 Å
- 6W4S chain F against the predicted model Q9NP59: TM-score 0.96, RMSD 1.64 Å
- 6W4S chain F against the predicted model Q9NP59: TM-score 0.96, RMSD 1.64 Å
Elsewhere
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