AlphaFold monomer V2.0 prediction for thiamine transporter 2 (Q9BZV2)

Structure

1 distinct chain · 69% helix, 0% strand (DSSP).

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 8XV2 · Thiamine-bound human SLC19A3 · an experimental structure of the same protein · chain A against A, TM-score 0.77
• 8XV5 · Pyridoxamine-bound human SLC19A3 · an experimental structure of the same protein · chain A against A, TM-score 0.77
• 8XV9 · Fedratinib-bound human SLC19A3 · an experimental structure of the same protein · chain A against A, TM-score 0.77
• 9G5K · Cryo-EM structure of apo human SLC19A3 in inward-open state · an experimental structure of the same protein · chain A against A, TM-score 0.76
• 8S61 · Cryo-EM structure of thiamine-bound human SLC19A3 in inward-open state · an experimental structure of the same protein · chain A against A, TM-score 0.76
• 8S5W · Cryo-EM structure of fedratinib-bound human SLC19A3 in inward-open state · an experimental structure of the same protein · chain A against A, TM-score 0.76
• 8S5Z · Cryo-EM structure of hydroxychloroquine-bound human SLC19A3 in inward-open state · an experimental structure of the same protein · chain A against A, TM-score 0.76
• 8S62 · Cryo-EM structure of amprolium-bound human SLC19A3 in inward-open state · an experimental structure of the same protein · chain A against A, TM-score 0.76
• 8S4U · Cryo-EM structure of apo human SLC19A3 in outward-open state · an experimental structure of the same protein · chain A against A, TM-score 0.63
• 8S5U · Cryo-EM structure of thiamine-bound human SLC19A3 in outward-open state · an experimental structure of the same protein · chain A against A, TM-score 0.63

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9BZV2
• Elsewhere: UniProt Q9BZV2 · AlphaFold DB Q9BZV2