UniProt Q9BZV2
Thiamine transporter 2 (Q9BZV2)
Thiamine transporter 2 (UniProt Q9BZV2): 10 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9BZV2
- Protein
- Thiamine transporter 2
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 28 · 11 records with a druggable one
Structures
11 records of Q9BZV2 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8S4U | Cryo-EM structure of apo human SLC19A3 in outward-open state | electron microscopy | A | NAG | 2 (best 0.85) |
| 8S5U | Cryo-EM structure of thiamine-bound human SLC19A3 in outward-open state | electron microscopy | A | NAG, VIB | 2 (best 0.84) |
| 8S5W | Cryo-EM structure of fedratinib-bound human SLC19A3 in inward-open state | electron microscopy | A | 2TA | 2 (best 0.85) |
| 8S5Z | Cryo-EM structure of hydroxychloroquine-bound human SLC19A3 in inward-open state | electron microscopy | A | NAG, A1H5D | 2 (best 0.84) |
| 8S61 | Cryo-EM structure of thiamine-bound human SLC19A3 in inward-open state | electron microscopy | A | VIB | 2 (best 0.83) |
| 8S62 | Cryo-EM structure of amprolium-bound human SLC19A3 in inward-open state | electron microscopy | A | A1H5C | 2 (best 0.83) |
| 8XV2 | Thiamine-bound human SLC19A3 | electron microscopy | A | VIB | 3 (best 0.85) |
| 8XV5 | Pyridoxamine-bound human SLC19A3 | electron microscopy | A | PXM | 4 (best 0.83) |
| 8XV9 | Fedratinib-bound human SLC19A3 | electron microscopy | A | 2TA | 4 (best 0.86) |
| 9G5K | Cryo-EM structure of apo human SLC19A3 in inward-open state | electron microscopy | A | NAG | 4 (best 0.83) |
| Q9BZV2 | AlphaFold monomer V2.0 prediction for thiamine transporter 2 (Q9BZV2) | predicted | A | — | 1 (best 0.87) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- VIB · 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium · in 3 records
- 2TA · N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl) ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide · in 2 records
- A1H5C · Amprolium · in 1 record
- A1H5D · Hydroxychloroquine · in 1 record
- PXM · 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol · in 1 record
Experiment against prediction
- 9G5K chain A against the predicted model Q9BZV2: TM-score 0.99, RMSD 0.77 Å
- 8S61 chain A against the predicted model Q9BZV2: TM-score 0.99, RMSD 0.75 Å
- 8S5W chain A against the predicted model Q9BZV2: TM-score 0.99, RMSD 0.76 Å
- 8S5Z chain A against the predicted model Q9BZV2: TM-score 0.99, RMSD 0.79 Å
- 8S62 chain A against the predicted model Q9BZV2: TM-score 0.99, RMSD 0.80 Å
- 8XV2 chain A against the predicted model Q9BZV2: TM-score 0.99, RMSD 0.89 Å
- 8XV5 chain A against the predicted model Q9BZV2: TM-score 0.98, RMSD 0.99 Å
- 8XV9 chain A against the predicted model Q9BZV2: TM-score 0.98, RMSD 1.20 Å
- 8S4U chain A against the predicted model Q9BZV2: TM-score 0.81, RMSD 3.71 Å
- 8S5U chain A against the predicted model Q9BZV2: TM-score 0.81, RMSD 3.71 Å
Elsewhere
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