Research workbench
AlphaFold monomer V2.0 prediction for solute carrier family 12 member 4 (Q9UP95)
Analyse AlphaFold monomer V2.0 prediction for solute carrier family 12 member 4 (Q9UP95) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9UP95
- Type
- protein
- Length
- 1,085 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x71351b1FB9B1B80D8d60E1f869F762a9c785B183
- Molecule
- Solute carrier family 12 member 4
- UniProt
- Q9UP95
- Pockets
- 14 · best druggability 0.76
Structure
1 distinct chain · 54% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Solute carrier family 12 member 4 | protein | 1085 | 54% helix, 9% strand | Q9UP95 |
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.76 | 0.97 | 31 | empty |
| 2 | 553 | 0.72 | 0.80 | 47 | empty |
| 3 | 470 | 0.68 | 0.79 | 51 | empty |
| 4 | 284 | 0.67 | 0.82 | 33 | empty |
| 5 | 372 | 0.55 | 0.74 | 35 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7AIQ · Structure of human potassium chloride transporter KCC1 in nacl (subclass 1) · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 7AIR · Structure of human potassium chloride transporter KCC1 in nacl (subclass 2) · an experimental structure of the same protein · chain A against B, TM-score 0.78
- 7AIP · Structure of human potassium chloride transporter KCC1 in nacl (reference MAP) · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 7TTH · Human potassium-chloride cotransporter 1 in inward-open state · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 6KKR · human KCC1 structure determined in KCl and detergent GDN · an experimental structure of the same protein · chain A against A, TM-score 0.49
- 6KKR · Human KCC1 structure determined in kcl and detergent gdn · an experimental structure of the same protein · chain A against A, TM-score 0.49
- 6KKT · Human KCC1 structure determined in kcl and lipid nanodisc · an experimental structure of the same protein · chain A against A, TM-score 0.49
- 6KKT · human KCC1 structure determined in KCl and lipid nanodisc · an experimental structure of the same protein · chain A against A, TM-score 0.49
- 6KKU · Human KCC1 structure determined in nacl and gdn · an experimental structure of the same protein · chain A against A, TM-score 0.49
- 6KKU · human KCC1 structure determined in NaCl and GDN · an experimental structure of the same protein · chain A against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UP95
- Elsewhere: UniProt Q9UP95 · AlphaFold DB Q9UP95
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