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AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta (P9WGY9)

Analyse AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession
P9WGY9
Type
protein
Length
1,178 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0x9073C46348542FfE4327c3F363F9B51B22058e75
Molecule
DNA-directed RNA polymerase subunit beta
UniProt
P9WGY9
Pockets
18 · best druggability 0.75

Structure

1 distinct chain · 27% helix, 26% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADNA-directed RNA polymerase subunit betaprotein117827% helix, 26% strandP9WGY9

Pockets

18 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
16710.750.8175empty
2740.720.9723empty
37890.700.7672empty
43250.660.8152empty
52630.650.8232empty

Compared structures

  • 6JCY · Mycobacterium tuberculosis RNA polymerase transcription initiation open complex with a… · an experimental structure of the same protein · chain A against C, TM-score 0.96
  • 6JCY · Mycobacterium tuberculosis RNA polymerase transcription initiation open complex with a… · an experimental structure of the same protein · chain A against C, TM-score 0.96
  • 6KOP · Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA… · an experimental structure of the same protein · chain A against C, TM-score 0.96
  • 6KOP · Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-oh RNA… · an experimental structure of the same protein · chain A against C, TM-score 0.96
  • 6KOQ · Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA… · an experimental structure of the same protein · chain A against C, TM-score 0.96
  • 6KOQ · Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-oh RNA… · an experimental structure of the same protein · chain A against C, TM-score 0.96
  • 6JCX · Mycobacterium tuberculosis transcription initiation complex with ECF sigma factor sigma H… · an experimental structure of the same protein · chain A against C, TM-score 0.95
  • 6JCX · Mycobacterium tuberculosis transcription initiation complex with ecf sigma factor sigma H… · an experimental structure of the same protein · chain A against C, TM-score 0.95
  • 6KOO · Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA… · an experimental structure of the same protein · chain A against C, TM-score 0.95
  • 6KOO · Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-oh RNA… · an experimental structure of the same protein · chain A against C, TM-score 0.95
  • 5ZX2 · Mycobacterium tuberculosis RNA polymerase transcription initiation complex with ECF sigma… · an experimental structure of the same protein · chain A against C, TM-score 0.95
  • 5ZX2 · Mycobacterium tuberculosis RNA polymerase transcription initiation complex with ecf sigma… · an experimental structure of the same protein · chain A against C, TM-score 0.95

Analyse

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