UniProt P9WGY9
DNA-directed RNA polymerase subunit beta (P9WGY9)
DNA-directed RNA polymerase subunit beta (UniProt P9WGY9), EC 2.7.7.6: 49 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 272 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P9WGY9
- Protein
- DNA-directed RNA polymerase subunit beta
- EC
- 2.7.7.6
- Experimental structures
- 49
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 272 · 19 records with a druggable one
Structures
50 records of P9WGY9 in the MolNFT archive: 49 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5UH5 | Crystal structure of mycobacterium tuberculosis transcription initiation complex containing 3 nt of… | x-ray diffraction | C | — | — |
| 5UH6 | Crystal structure of mycobacterium tuberculosis transcription initiation complex containing 2NTRNA… | x-ray diffraction | C | RFP | — |
| 5UH8 | Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 4nt RNA | x-ray diffraction | C | — | 15 (best 0.84) |
| 5UH8 | Crystal structure of mycobacterium tuberculosis transcription initiation complex containing 4NT RNA | x-ray diffraction | C | — | — |
| 5UH9 | Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 2nt RNA | x-ray diffraction | C | — | 14 (best 0.83) |
| 5UH9 | Crystal structure of mycobacterium tuberculosis transcription initiation complex containing 2NT RNA | x-ray diffraction | C | — | — |
| 5UHA | Crystal structure of Mycobacterium tuberculosis transcription initiation complex | x-ray diffraction | C | — | 15 (best 0.84) |
| 5UHA | Crystal structure of mycobacterium tuberculosis transcription initiation complex | x-ray diffraction | C | — | — |
| 5UHB | Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with… | x-ray diffraction | C | RFP | 15 (best 0.81) |
| 5UHB | Crystal structure of mycobacterium tuberculosis transcription initiation complex in complex with… | x-ray diffraction | C | RFP | — |
| 5UHC | Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 3nt RNA… | x-ray diffraction | C | RFP | 14 (best 0.83) |
| 5UHC | Crystal structure of mycobacterium tuberculosis transcription initiation complex containing 3NT RNA… | x-ray diffraction | C | RFP | — |
| 5UHD | Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 4nt RNA… | x-ray diffraction | C | RFP | 17 (best 0.83) |
| 5UHD | Crystal structure of mycobacterium tuberculosis transcription initiation complex containing 4NT RNA… | x-ray diffraction | C | RFP | — |
| 5UHE | Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with… | x-ray diffraction | C | 88G | 16 (best 0.82) |
| 5UHE | Crystal structure of mycobacterium tuberculosis transcription initiation complex in complex with… | x-ray diffraction | C | — | — |
| 5UHF | Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with… | x-ray diffraction | C | 88D | 13 (best 0.83) |
| 5UHF | Crystal structure of mycobacterium tuberculosis transcription initiation complex in complex with… | x-ray diffraction | C | — | — |
| 5UHG | Crystal structure of mycobacterium tuberculosis transcription initiation complex in complex with… | x-ray diffraction | C | RFP | — |
| 5ZX2 | Mycobacterium tuberculosis RNA polymerase transcription initiation complex with ECF sigma factor… | x-ray diffraction | C | — | 17 (best 0.87) |
| 5ZX2 | Mycobacterium tuberculosis RNA polymerase transcription initiation complex with ecf sigma factor… | x-ray diffraction | C | — | — |
| 5ZX3 | Mycobacterium tuberculosis RNA polymerase holoenzyme with ECF sigma factor sigma H | x-ray diffraction | C | — | 13 (best 0.86) |
| 5ZX3 | Mycobacterium tuberculosis RNA polymerase holoenzyme with ecf sigma factor sigma H | x-ray diffraction | C | — | — |
| 6DV9 | Crystal structure of mycobacterium tuberculosis transcription initiation COMPLEX(ECF sigma factor… | x-ray diffraction | C | — | — |
| 6DVB | Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF sigma factor… | x-ray diffraction | C | — | — |
| 6DVB | Crystal structure of mycobacterium tuberculosis transcription initiation COMPLEX(ECF sigma factor… | x-ray diffraction | C | — | — |
| 6DVC | Crystal structure of mycobacterium tuberculosis transcription initiation COMPLEX(ECF sigma factor… | x-ray diffraction | C | — | — |
| 6DVD | Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF sigma factor… | x-ray diffraction | C | — | — |
| 6DVD | Crystal structure of mycobacterium tuberculosis transcription initiation COMPLEX(ECF sigma factor… | x-ray diffraction | C | — | — |
| 6DVE | Crystal structure of mycobacterium tuberculosis transcription initiation COMPLEX(ECF… | x-ray diffraction | C | — | — |
| 6FBV | Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with… | electron microscopy | C | FI8 | 16 (best 0.82) |
| 6FBV | Single particle cryo EM structure of mycobacterium tuberculosis RNA polymerase in complex with… | electron microscopy | C | FI8 | — |
| 6JCX | Mycobacterium tuberculosis transcription initiation complex with ECF sigma factor sigma H and 6nt… | x-ray diffraction | C | — | 16 (best 0.85) |
| 6JCX | Mycobacterium tuberculosis transcription initiation complex with ecf sigma factor sigma H and 6NT… | x-ray diffraction | C | — | — |
| 6JCY | Mycobacterium tuberculosis RNA polymerase transcription initiation open complex with a chimeric ECF… | x-ray diffraction | C | — | 15 (best 0.85) |
| 6JCY | Mycobacterium tuberculosis RNA polymerase transcription initiation open complex with a chimeric ecf… | x-ray diffraction | C | — | — |
| 6KON | Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 5 nt | x-ray diffraction | C | — | — |
| 6KON | Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-oh RNA of 5 nt | x-ray diffraction | C | — | — |
| 6KOO | Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 7 nt | x-ray diffraction | C | — | — |
| 6KOO | Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-oh RNA of 7 nt | x-ray diffraction | C | — | — |
| 6KOP | Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 9 nt | x-ray diffraction | C | — | — |
| 6KOP | Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-oh RNA of 9 nt | x-ray diffraction | C | — | — |
| 6KOQ | Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-oh RNA of 10 nt | x-ray diffraction | C | — | — |
| 8CWR | Complex structure of WhiB3 and the SigmaAr4-RNAP Beta flap tip chimera in space group R3 | x-ray diffraction | B | SF4, SO4, NI | 1 (best 0.61) |
| 8CWT | Complex structure of WhiB3 and the SigmaAr4-RNAP Beta flap tip chimera in space group P43212 | x-ray diffraction | B, D, F | SF4, NI, SO4 | 9 (best 0.49) |
| 8D5V | WhiB6 bound to the SigmaAr4-RNAP Beta flap tip chimera | x-ray diffraction | B, D | SF4 | 3 (best 0.56) |
| 8EHQ | Mycobacterium tuberculosis paused transcription complex with Bacillus subtilis NusG | electron microscopy | C | — | 14 (best 0.84) |
| 8EOS | M. tuberculosis RNAP elongation complex with NusG and CMPCPP | electron microscopy | C | 2TM | 15 (best 0.87) |
| 8EOT | M. tuberculosis RNAP elongation complex with NusG | electron microscopy | C | — | 16 (best 0.85) |
| P9WGY9 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta (P9WGY9) | predicted | A | — | 18 (best 0.75) |
Ligands
- RFP · Rifampicin · in 8 records
- SF4 · Iron/sulfur cluster · in 3 records
- FI8 · Fidaxomicin · in 2 records
- NI · Nickel (II) ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- 2TM · 5'-O-[(S)-hydroxy{[(s)-hydroxy(phosphonooxy) phosphoryl]methyl}phosphoryl]cytidine · in 1 record
- 88D · N-(2-methylphenyl)-Nalpha-(selenophene-2-carbonyl)-D-phenylalaninamide · in 1 record
- 88G · Nalpha-(benzenecarbonyl)-N-(2-methylphenyl)-D-phenylalaninamide · in 1 record
Experiment against prediction
- 6KON chain C against the predicted model P9WGY9: TM-score 0.99, RMSD 1.00 Å
- 6KON chain C against the predicted model P9WGY9: TM-score 0.99, RMSD 1.00 Å
- 5ZX3 chain C against the predicted model P9WGY9: TM-score 0.99, RMSD 1.10 Å
- 5ZX3 chain C against the predicted model P9WGY9: TM-score 0.99, RMSD 1.10 Å
- 5UHD chain C against the predicted model P9WGY9: TM-score 0.99, RMSD 1.00 Å
- 5UHD chain C against the predicted model P9WGY9: TM-score 0.99, RMSD 1.00 Å
- 5UHB chain C against the predicted model P9WGY9: TM-score 0.99, RMSD 1.02 Å
- 5UHB chain C against the predicted model P9WGY9: TM-score 0.99, RMSD 1.02 Å
- 5UHG chain C against the predicted model P9WGY9: TM-score 0.99, RMSD 1.05 Å
- 5UHF chain C against the predicted model P9WGY9: TM-score 0.99, RMSD 1.05 Å
Elsewhere
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