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AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC6 (Q9H1D9)

Analyse AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession
Q9H1D9
Type
protein
Length
316 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0x5BeA89782341f98147F2D811B063F91F0aE7D7bF
Molecule
DNA-directed RNA polymerase III subunit RPC6
UniProt
Q9H1D9
Pockets
1 · best druggability 0.28

Structure

1 distinct chain · 50% helix, 15% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADNA-directed RNA polymerase III subunit RPC6protein31650% helix, 15% strandQ9H1D9

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1730.280.7217empty

Compared structures

  • 8IUH · RNA polymerase III pre-initiation complex open complex 1 · an experimental structure of the same protein · chain A against P, TM-score 0.60
  • 8IUE · RNA polymerase III pre-initiation complex melting complex 1 · an experimental structure of the same protein · chain A against P, TM-score 0.59
  • 8ITY · human RNA polymerase III pre-initiation complex closed DNA 1 · an experimental structure of the same protein · chain A against P, TM-score 0.55
  • 7A6H · Cryo-EM structure of human apo RNA polymerase III · an experimental structure of the same protein · chain A against P, TM-score 0.34
  • 7A6H · Cryo-EM structure of human apo RNA Polymerase III · an experimental structure of the same protein · chain A against P, TM-score 0.34
  • 7AE3 · Cryo-EM structure of human RNA Polymerase III elongation complex 3 · an experimental structure of the same protein · chain A against P, TM-score 0.34
  • 7AE3 · Cryo-EM structure of human RNA polymerase III elongation complex 3 · an experimental structure of the same protein · chain A against P, TM-score 0.34
  • 7AEA · Cryo-EM structure of human RNA polymerase III elongation complex 2 · an experimental structure of the same protein · chain A against P, TM-score 0.34
  • 7AEA · Cryo-EM structure of human RNA Polymerase III elongation complex 2 · an experimental structure of the same protein · chain A against P, TM-score 0.34
  • 7AE1 · Cryo-EM structure of human RNA Polymerase III elongation complex 1 · an experimental structure of the same protein · chain A against P, TM-score 0.34
  • 7AE1 · Cryo-EM structure of human RNA polymerase III elongation complex 1 · an experimental structure of the same protein · chain A against P, TM-score 0.34
  • 7D58 · Cryo-EM structure of human RNA polymerase III in elongating state · an experimental structure of the same protein · chain A against P, TM-score 0.31

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